KEGG   NETWORK: N01680
Entry
N01680                      Network                                
Name
NOR antigen biosynthesis
Definition
LacCer -- A4GALT*NOR -> Pk -- B3GALNT1*P -> P -- A4GALT*NOR -> NOR1 -- B3GALNT1*P -> NORint -- A4GALT*NOR -> NOR2
  Expanded
G00092 -- 53947v2 -> G00093 -- 8706v1 -> G00094 -- 53947v2 -> G11492 -- 8706v1 -> G13080 -- 53947v2 -> G13081
Class
nt06035 Blood group carbohydrate antigen biosynthesis
Type
Reference
Pathway
hsa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
Gene
53947  A4GALT; alpha 1,4-galactosyltransferase (P blood group)
8706  B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
Variant
53947v2 (A4GALT*NOR)  A4GALT P1+, Pk+, NOR+ allele
8706v1 (B3GALNT1*P)  B3GALNT1 P+ allele
Metabolite
G00092  Lactosylceramide
G00093  Globotriaosylceramide
G00094  Globoside
G11492  IV4-alpha-Gal-Gb4Cer
G13080  NORint
G13081  NOR2 antigen
Reference
PMID:26773500
  Authors
Kaczmarek R, Duk M, Szymczak K, Korchagina E, Tyborowska J, Mikolajczyk K, Bovin N, Szewczyk B, Jaskiewicz E, Czerwinski M
  Title
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR  blood group antigens.
  Journal
Biochem Biophys Res Commun 470:168-174 (2016)
DOI:10.1016/j.bbrc.2016.01.017
Reference
PMID:22965229
  Authors
Suchanowska A, Kaczmarek R, Duk M, Lukasiewicz J, Smolarek D, Majorczyk E, Jaskiewicz E, Laskowska A, Wasniowska K, Grodecka M, Lisowska E, Czerwinski M.
  Title
A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome.
  Journal
J Biol Chem 287:38220-30 (2012)
DOI:10.1074/jbc.M112.408286
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