KEGG   NETWORK: N01749
Entry
N01749                      Network                                
Name
Find-me signal (CX3CL1)
Definition
CASP3,ADAM10,ADAM17 -> CXCL1 -> CX3CR1 => MEGF8
  Expanded
836,102,6868 -> 2919 -> 1524 => 1954
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
836  CASP3; caspase 3
102  ADAM10; ADAM metallopeptidase domain 10
6868  ADAM17; ADAM metallopeptidase domain 17
2919  CXCL1; C-X-C motif chemokine ligand 1
1524  CX3CR1; C-X3-C motif chemokine receptor 1
1954  MEGF8; multiple EGF like domains 8
Reference
PMID:32694395
  Authors
Li Y, Li Q, Fan GC
  Title
Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.
  Journal
Shock 55:177-188 (2021)
DOI:10.1097/SHK.0000000000001625
Reference
PMID:34685562
  Authors
Tsai WH, Chang SC, Lin YC, Hsu HC
  Title
CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages.
  Journal
Cells 10:cells10102583 (2021)
DOI:10.3390/cells10102583
Reference
PMID:11495925
  Authors
Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ, Raines EW
  Title
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
  Journal
J Biol Chem 276:37993-8001 (2001)
DOI:10.1074/jbc.M106434200
Reference
PMID:12714508
  Authors
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A
  Title
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell  adhesion.
  Journal
Blood 102:1186-95 (2003)
DOI:10.1182/blood-2002-12-3775
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