| Entry |
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| Name |
Activation of CRK-DOCK-Rac1 pathway
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| Definition |
PtdSer(outer) -> MFGE8 -> (ITGAV+ITGB3,ITGB5) -> FAK -> (CAS+CRK) -> (DOCK1+ELMO1) -> RAC1 |
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| Expanded |
C02737 -> 4240 -> (3685+3690,3693) -> 5747 -> (9564+1398) -> (1793+9844) -> 5879 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 4240 | MFGE8; milk fat globule EGF and factor V/VIII domain containing |
| 3685 | ITGAV; integrin subunit alpha V |
| 3690 | ITGB3; integrin subunit beta 3 |
| 3693 | ITGB5; integrin subunit beta 5 |
| 5747 | PTK2; protein tyrosine kinase 2 |
| 9564 | BCAR1; BCAR1 scaffold protein, Cas family member |
| 1398 | CRK; CRK proto-oncogene, adaptor protein |
| 1793 | DOCK1; dedicator of cytokinesis 1 |
| 9844 | ELMO1; engulfment and cell motility 1 |
| 5879 | RAC1; Rac family small GTPase 1 |
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| Metabolite |
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| Reference |
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| Authors |
Park SY, Kim IS |
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| Title |
Engulfment signals and the phagocytic machinery for apoptotic cell clearance. |
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| Journal |
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| Reference |
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| Authors |
Kumar S, Calianese D, Birge RB |
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| Title |
Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment. |
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| Journal |
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| Reference |
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| Authors |
Lam AL, Heit B |
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| Title |
Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes. |
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| Journal |
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| Reference |
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| Authors |
Akakura S, Singh S, Spataro M, Akakura R, Kim JI, Albert ML, Birge RB |
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| Title |
The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. |
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| Journal |
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| LinkDB |
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