| Entry |
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| Gene name |
CRK, CRKII, p38
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| Definition |
(RefSeq) CRK proto-oncogene, adaptor protein
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| KO |
| K04438 | C-crk adapter molecule crk |
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| Organism |
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| Pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04935 | Growth hormone synthesis, secretion and action |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa05163 | Human cytomegalovirus infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
nt06124 Chemokine signaling (viruses) nt06135 Cytoskeletal regulation (viruses and bacteria) nt06167 Human cytomegalovirus (HCMV) nt06214 PI3K signaling nt06276 Chronic myeloid leukemia |
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| Element |
| N00048 | BCR-ABL fusion kinase to PI3K signaling pathway |
| N00413 | CXCR4-GNB/G-PLCB-PKC signaling pathway |
| N00414 | HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway |
| N01068 | ITGA/B-FAK-RAC signaling pathway |
| N01090 | IGG-FCGR-RAC signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
1398 (CRK)
04012 ErbB signaling pathway
1398 (CRK)
04015 Rap1 signaling pathway
1398 (CRK)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
1398 (CRK)
09142 Cell motility
04810 Regulation of actin cytoskeleton
1398 (CRK)
09150 Organismal Systems
09151 Immune system
04666 Fc gamma R-mediated phagocytosis
1398 (CRK)
04062 Chemokine signaling pathway
1398 (CRK)
09152 Endocrine system
04910 Insulin signaling pathway
1398 (CRK)
04935 Growth hormone synthesis, secretion and action
1398 (CRK)
09156 Nervous system
04722 Neurotrophin signaling pathway
1398 (CRK)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1398 (CRK)
05206 MicroRNAs in cancer
1398 (CRK)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
1398 (CRK)
05211 Renal cell carcinoma
1398 (CRK)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
1398 (CRK)
05163 Human cytomegalovirus infection
1398 (CRK)
09171 Infectious disease: bacterial
05131 Shigellosis
1398 (CRK)
05135 Yersinia infection
1398 (CRK)
05100 Bacterial invasion of epithelial cells
1398 (CRK)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
1398 (CRK)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
Src homology (SH) domain-containing proteins
Other SH2 and SH3-containing proteins
1398 (CRK)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
17p13.3
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| AA seq |
304 aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS |
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| NT seq |
915 nt +upstreamnt +downstreamnt
atggcgggcaacttcgactcggaggagcggagtagctggtactgggggaggttgagtcgg
caggaggcggtggcgctgctgcagggccagcggcacggggtgttcctggtgcgggactcg
agcaccagccccggggactatgtgctcagcgtctcagagaactcgcgcgtctcccactac
atcatcaacagcagcggcccgcgcccgccggtgccaccgtcgcccgcccagcctccgccc
ggggtgagcccctccagactccgaataggagatcaagagtttgattcattgcctgcttta
ctggaattctacaaaatacactatttggacactacaacgttgatagaaccagtttccaga
tccaggcagggtagtggagtgattctcaggcaggaggaggcggagtatgtgcgagccctc
tttgactttaatgggaatgatgaggaagatcttccctttaagaaaggagacatcttgaga
atccgggacaagcctgaagagcagtggtggaatgcggaggacagcgaaggcaagagaggg
atgattccagtcccttacgtcgagaagtatagacctgcctccgcctcagtatcggctctg
attggaggtaaccaggagggttcccacccacagccactgggtgggccggagcctgggccc
tatgcccaacccagcgtcaacactccgctccctaacctccagaatgggcccatatatgcc
agggttatccagaagcgagtccccaatgcctacgacaagacagccttggctttggaggtc
ggtgagctggtaaaggttacgaagattaatgtgagtggtcagtgggaaggggagtgtaat
ggcaaacgaggtcacttcccattcacacatgtccgtctgctggatcaacagaatcccgat
gaggacttcagctga |
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