KEGG   NETWORK: N01763
Entry
N01763                      Network                                
Name
MEGF10-mediated recognition and engulfment
Definition
PtdSer(outer) -> (C1QA,C1QB,C1QC) -> MEGF10 -> GULP1 -> RAC1
  Expanded
C02737 -> (712,713,714) -> 84466 -> 51454 -> 5879
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
84466  MEGF10; multiple EGF like domains 10
51454  GULP1; GULP PTB domain containing engulfment adaptor 1
5879  RAC1; Rac family small GTPase 1
Metabolite
C02737  Phosphatidylserine
Reference
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
  Authors
Iram T, Ramirez-Ortiz Z, Byrne MH, Coleman UA, Kingery ND, Means TK, Frenkel D, El Khoury J
  Title
Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes.
  Journal
J Neurosci 36:5185-92 (2016)
DOI:10.1523/JNEUROSCI.3850-15.2016
Reference
  Authors
Hamon Y, Trompier D, Ma Z, Venegas V, Pophillat M, Mignotte V, Zhou Z, Chimini G
  Title
Cooperation between engulfment receptors: the case of ABCA1 and MEGF10.
  Journal
PLoS One 1:e120 (2006)
DOI:10.1371/journal.pone.0000120
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