KEGG   NETWORK: N01772
Entry
N01772                      Network                                
Name
Induction of the PTGS2
Definition
THBS1 -> CD36 -> MEK -> ERK => PTGS2
  Expanded
7057 -> 948 -> (5604,5605) -> (5594,5595) => 5743
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
7057  THBS1; thrombospondin 1
948  CD36; CD36 molecule
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
5743  PTGS2; prostaglandin-endoperoxide synthase 2
Reference
  Authors
Ampomah PB, Cai B, Sukka SR, Gerlach BD, Yurdagul A Jr, Wang X, Kuriakose G, Darville LNF, Sun Y, Sidoli S, Koomen JM, Tall AR, Tabas I
  Title
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution.
  Journal
Nat Metab 4:444-457 (2022)
DOI:10.1038/s42255-022-00551-7
Reference
  Authors
Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Zhen X, Ying Z, Wang G
  Title
Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.
  Journal
Cell Death Dis 6:e1702 (2015)
DOI:10.1038/cddis.2015.69
Reference
  Authors
Xiong W, Frasch SC, Thomas SM, Bratton DL, Henson PM
  Title
Induction of TGF-beta1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36.
  Journal
PLoS One 8:e72772 (2013)
DOI:10.1371/journal.pone.0072772
Reference
  Authors
Ramirez MU, Stirling ER, Emenaker NJ, Roberts DD, Soto-Pantoja DR
  Title
Thrombospondin-1 interactions regulate eicosanoid metabolism and signaling in cancer-related inflammation.
  Journal
Cancer Metastasis Rev 37:469-476 (2018)
DOI:10.1007/s10555-018-9737-x
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