Entry |
|
Symbol |
MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
|
Name |
(RefSeq) mitogen-activated protein kinase 1
|
KO |
|
Organism |
|
Pathway |
hsa01521 | EGFR tyrosine kinase inhibitor resistance |
hsa04072 | Phospholipase D signaling pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
hsa04270 | Vascular smooth muscle contraction |
hsa04550 | Signaling pathways regulating pluripotency of stem cells |
hsa04613 | Neutrophil extracellular trap formation |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa04664 | Fc epsilon RI signaling pathway |
hsa04666 | Fc gamma R-mediated phagocytosis |
hsa04723 | Retrograde endocannabinoid signaling |
hsa04810 | Regulation of actin cytoskeleton |
hsa04914 | Progesterone-mediated oocyte maturation |
hsa04919 | Thyroid hormone signaling pathway |
hsa04928 | Parathyroid hormone synthesis, secretion and action |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
hsa04935 | Growth hormone synthesis, secretion and action |
hsa04960 | Aldosterone-regulated sodium reabsorption |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05163 | Human cytomegalovirus infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05207 | Chemical carcinogenesis - receptor activation |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
hsa05230 | Central carbon metabolism in cancer |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
|
Element |
N00001 | EGF-EGFR-RAS-ERK signaling pathway |
N00002 | BCR-ABL fusion kinase to RAS-ERK signaling pathway |
N00003 | Mutation-activated KIT to RAS-ERK signaling pathway |
N00004 | Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway |
N00005 | Mutation-activated MET to RAS-ERK signaling pathway |
N00006 | Amplified EGFR to RAS-ERK signaling pathway |
N00007 | EML4-ALK fusion kinase to RAS-ERK signaling pathway |
N00008 | RET fusion kinase to RAS-ERK signaling pathway |
N00009 | TRK fusion kinase to RAS-ERK signaling pathway |
N00011 | Mutation-activated FGFR3 to RAS-ERK signaling pathway |
N00012 | Mutation-activated KRAS/NRAS to ERK signaling pathway |
N00013 | Mutation-activated BRAF to ERK signaling pathway |
N00014 | Mutation-activated EGFR to RAS-ERK signaling pathway |
N00015 | PDGF-PDGFR-RAS-ERK signaling pathway |
N00016 | PDGF-overexpression to RAS-ERK signaling pathway |
N00018 | Amplified PDGFR to RAS-ERK signaling pathway |
N00019 | FGF-FGFR-RAS-ERK signaling pathway |
N00020 | Amplified FGFR to RAS-ERK signaling pathway |
N00021 | EGF-ERBB2-RAS-ERK signaling pathway |
N00022 | ERBB2-overexpression to RAS-ERK signaling pathway |
N00023 | EGF-EGFR-PLCG-ERK signaling pathway |
N00024 | Mutation-activated EGFR to PLCG-ERK signaling pathway |
N00025 | EML4-ALK fusion kinase to PLCG-ERK signaling pathway |
N00041 | EGFR-overexpression to RAS-ERK signaling pathway |
N00077 | HRAS-overexpression to ERK signaling pathway |
N00078 | Mutation-activated HRAS to ERK signaling pathway |
N00152 | CXCR-GNB/G-ERK signaling pathway |
N00215 | KITLG-KIT-RAS-ERK signaling pathway |
N00216 | HGF-MET-RAS-ERK signaling pathway |
N00217 | FLT3LG-FLT3-RAS-ERK signaling pathway |
N00229 | TGFA-EGFR-RAS-ERK signaling pathway |
N00230 | TGFA-overexpression to RAS-ERK signaling pathway |
N00233 | IGF-IGF1R-RAS-ERK signaling pathway |
N00235 | IGF2-overexpression to RAS-ERK signaling pathway |
N00237 | IGF1R-overexpression to RAS-ERK signaling pathway |
N00246 | HGF-overexpression to RAS-ERK signaling pathway |
N00248 | MET-overexpression to RAS-ERK signaling pathway |
N00252 | Amplified ERBB2 to RAS-ERK signaling pathway |
N00259 | Amplified MET to RAS-ERK signaling pathway |
N00276 | EGF-overexpression to RAS-ERK signaling pathway |
N00277 | EREG-EGFR-RAS-ERK signaling pathway |
N00278 | EREG-overexpression to RAS-ERK signaling pathway |
N00279 | AREG-EGFR-RAS-ERK signaling pathway |
N00280 | AREG-overexpression to RAS-ERK signaling pathway |
N00318 | EGFR-ERK-ACTH signaling pathway |
N00319 | Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway |
N00367 | HPV E5 to EGFR-RAS-ERK signaling pathway |
N00386 | HCMV gB to PDGFR-RAS-ERK signaling pathway |
N00438 | TLR2/4-MAPK signaling pathway |
N00439 | HIV Nef to TLR2/4-MAPK signaling pathway |
N00513 | Mutation-activated EGFR to RAS-ERK signaling pathway |
N00518 | HCV Core to ERK signaling pathway |
N00538 | Ca2+-PYK2-RAS-ERK signaling pathway |
N00540 | HBV HBx to RAS-ERK signaling pathway |
N00545 | HBV HBx to ERK signaling pathway |
N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
N00873 | GnRH-GnRHR-PLCB-PKC signaling pathway |
N00879 | PROK-PRKR-Gi-ERK signaling pathway |
N00994 | AGE-RAGE signaling pathway |
N00996 | Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway |
N01062 | Mutation-activated MET to RAS-ERK signaling pathway |
N01064 | Mutation-activated RET to RAS-ERK signaling pathway |
N01119 | RAC/CDC42-PAK-ERK signaling pathway |
N01121 | Salmonella SpvC to ERK signaling pathway |
N01204 | PRNP-PI3K-NOX2 signaling pathway |
N01283 | Shigella OspF to TLR2/4-MAPK signaling pathway |
N01343 | ACH-CHRN-RAS-ERK signaling pathway |
N01344 | NNK/NNN to RAS-ERK signaling pathway |
N01351 | E2-ER-RAS-ERK signaling pathway |
N01352 | BPA to RAS-ERK signaling pathway |
N01353 | E2 to RAS-ERK signaling pathway |
N01354 | BPA to RAS-ERK signaling pathway |
N01360 | P4-PR-RAS-ERK signaling pathway |
N01361 | P4/MPA to PR-RAS-ERK signaling pathway |
N01408 | Metals to RAS-ERK signaling pathway |
N01592 | GF-RTK-RAS-ERK signaling pathway |
N01593 | Regulation of GF-RTK-RAS-ERK signaling, PTP |
N01602 | ERK-MYC signaling pathway |
N01751 | Macrophage EPO signaling |
N01774 | ERK-DUSP4 negative feedback pathway |
N01775 | Inactivation of CaMKII by inducing SERCA2 |
N01823 | FGF23-NCC/NPT signaling pathway |
|
Disease |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5594 (MAPK1)
04012 ErbB signaling pathway
5594 (MAPK1)
04014 Ras signaling pathway
5594 (MAPK1)
04015 Rap1 signaling pathway
5594 (MAPK1)
04350 TGF-beta signaling pathway
5594 (MAPK1)
04370 VEGF signaling pathway
5594 (MAPK1)
04371 Apelin signaling pathway
5594 (MAPK1)
04668 TNF signaling pathway
5594 (MAPK1)
04066 HIF-1 signaling pathway
5594 (MAPK1)
04068 FoxO signaling pathway
5594 (MAPK1)
04072 Phospholipase D signaling pathway
5594 (MAPK1)
04071 Sphingolipid signaling pathway
5594 (MAPK1)
04024 cAMP signaling pathway
5594 (MAPK1)
04022 cGMP-PKG signaling pathway
5594 (MAPK1)
04151 PI3K-Akt signaling pathway
5594 (MAPK1)
04150 mTOR signaling pathway
5594 (MAPK1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5594 (MAPK1)
04148 Efferocytosis
5594 (MAPK1)
09143 Cell growth and death
04114 Oocyte meiosis
5594 (MAPK1)
04210 Apoptosis
5594 (MAPK1)
04218 Cellular senescence
5594 (MAPK1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
5594 (MAPK1)
04520 Adherens junction
5594 (MAPK1)
04540 Gap junction
5594 (MAPK1)
04550 Signaling pathways regulating pluripotency of stem cells
5594 (MAPK1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5594 (MAPK1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5594 (MAPK1)
04613 Neutrophil extracellular trap formation
5594 (MAPK1)
04620 Toll-like receptor signaling pathway
5594 (MAPK1)
04621 NOD-like receptor signaling pathway
5594 (MAPK1)
04625 C-type lectin receptor signaling pathway
5594 (MAPK1)
04650 Natural killer cell mediated cytotoxicity
5594 (MAPK1)
04660 T cell receptor signaling pathway
5594 (MAPK1)
04658 Th1 and Th2 cell differentiation
5594 (MAPK1)
04659 Th17 cell differentiation
5594 (MAPK1)
04657 IL-17 signaling pathway
5594 (MAPK1)
04662 B cell receptor signaling pathway
5594 (MAPK1)
04664 Fc epsilon RI signaling pathway
5594 (MAPK1)
04666 Fc gamma R-mediated phagocytosis
5594 (MAPK1)
04062 Chemokine signaling pathway
5594 (MAPK1)
09152 Endocrine system
04910 Insulin signaling pathway
5594 (MAPK1)
04929 GnRH secretion
5594 (MAPK1)
04912 GnRH signaling pathway
5594 (MAPK1)
04915 Estrogen signaling pathway
5594 (MAPK1)
04914 Progesterone-mediated oocyte maturation
5594 (MAPK1)
04917 Prolactin signaling pathway
5594 (MAPK1)
04921 Oxytocin signaling pathway
5594 (MAPK1)
04926 Relaxin signaling pathway
5594 (MAPK1)
04935 Growth hormone synthesis, secretion and action
5594 (MAPK1)
04919 Thyroid hormone signaling pathway
5594 (MAPK1)
04928 Parathyroid hormone synthesis, secretion and action
5594 (MAPK1)
04916 Melanogenesis
5594 (MAPK1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
5594 (MAPK1)
04270 Vascular smooth muscle contraction
5594 (MAPK1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
5594 (MAPK1)
09156 Nervous system
04724 Glutamatergic synapse
5594 (MAPK1)
04725 Cholinergic synapse
5594 (MAPK1)
04726 Serotonergic synapse
5594 (MAPK1)
04720 Long-term potentiation
5594 (MAPK1)
04730 Long-term depression
5594 (MAPK1)
04723 Retrograde endocannabinoid signaling
5594 (MAPK1)
04722 Neurotrophin signaling pathway
5594 (MAPK1)
09158 Development and regeneration
04360 Axon guidance
5594 (MAPK1)
04380 Osteoclast differentiation
5594 (MAPK1)
09159 Environmental adaptation
04713 Circadian entrainment
5594 (MAPK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5594 (MAPK1)
05206 MicroRNAs in cancer
5594 (MAPK1)
05205 Proteoglycans in cancer
5594 (MAPK1)
05207 Chemical carcinogenesis - receptor activation
5594 (MAPK1)
05208 Chemical carcinogenesis - reactive oxygen species
5594 (MAPK1)
05203 Viral carcinogenesis
5594 (MAPK1)
05230 Central carbon metabolism in cancer
5594 (MAPK1)
05231 Choline metabolism in cancer
5594 (MAPK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5594 (MAPK1)
09162 Cancer: specific types
05210 Colorectal cancer
5594 (MAPK1)
05212 Pancreatic cancer
5594 (MAPK1)
05225 Hepatocellular carcinoma
5594 (MAPK1)
05226 Gastric cancer
5594 (MAPK1)
05214 Glioma
5594 (MAPK1)
05216 Thyroid cancer
5594 (MAPK1)
05221 Acute myeloid leukemia
5594 (MAPK1)
05220 Chronic myeloid leukemia
5594 (MAPK1)
05218 Melanoma
5594 (MAPK1)
05211 Renal cell carcinoma
5594 (MAPK1)
05219 Bladder cancer
5594 (MAPK1)
05215 Prostate cancer
5594 (MAPK1)
05213 Endometrial cancer
5594 (MAPK1)
05224 Breast cancer
5594 (MAPK1)
05223 Non-small cell lung cancer
5594 (MAPK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5594 (MAPK1)
05170 Human immunodeficiency virus 1 infection
5594 (MAPK1)
05161 Hepatitis B
5594 (MAPK1)
05160 Hepatitis C
5594 (MAPK1)
05171 Coronavirus disease - COVID-19
5594 (MAPK1)
05164 Influenza A
5594 (MAPK1)
05163 Human cytomegalovirus infection
5594 (MAPK1)
05167 Kaposi sarcoma-associated herpesvirus infection
5594 (MAPK1)
05165 Human papillomavirus infection
5594 (MAPK1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
5594 (MAPK1)
05132 Salmonella infection
5594 (MAPK1)
05131 Shigellosis
5594 (MAPK1)
05135 Yersinia infection
5594 (MAPK1)
05133 Pertussis
5594 (MAPK1)
05152 Tuberculosis
5594 (MAPK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
5594 (MAPK1)
05140 Leishmaniasis
5594 (MAPK1)
05142 Chagas disease
5594 (MAPK1)
09164 Neurodegenerative disease
05010 Alzheimer disease
5594 (MAPK1)
05020 Prion disease
5594 (MAPK1)
05022 Pathways of neurodegeneration - multiple diseases
5594 (MAPK1)
09165 Substance dependence
05034 Alcoholism
5594 (MAPK1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5594 (MAPK1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
5594 (MAPK1)
04933 AGE-RAGE signaling pathway in diabetic complications
5594 (MAPK1)
04934 Cushing syndrome
5594 (MAPK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
5594 (MAPK1)
01524 Platinum drug resistance
5594 (MAPK1)
01522 Endocrine resistance
5594 (MAPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5594 (MAPK1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
5594 (MAPK1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
5594 (MAPK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
5594 (MAPK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CMGC group
MAPK family [OT]
5594 (MAPK1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centromeric chromatin formation proteins
SAC (spindle assembly checkpoint) factors
Protein kinases
5594 (MAPK1)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
5594 (MAPK1)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
22:complement(21759657..21867680)
|
AA seq |
360 aa
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS |
NT seq |
1083 nt +upstreamnt +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcgtacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagcccctttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgacattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaggacctcatggaaacagatctttacaagctcttgaagacacaacac
ctcagcaatgaccatatctgctattttctctaccagatcctcagagggttaaaatatatc
cattcagctaacgttctgcaccgtgacctcaagccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggcctggcccgtgttgcagatccagaccatgatcac
acagggttcctgacagaatatgtggccacacgttggtacagggctccagaaattatgttg
aattccaagggctacaccaagtccattgatatttggtctgtaggctgcattctggcagaa
atgctttctaacaggcccatctttccagggaagcattatcttgaccagctgaaccacatt
ttgggtattcttggatccccatcacaagaagacctgaattgtataataaatttaaaagct
aggaactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactccaaagctctggacttattggacaaaatgttgacattcaacccacacaag
aggattgaagtagaacaggctctggcccacccatatctggagcagtattacgacccgagt
gacgagcccatcgccgaagcaccattcaagttcgacatggaattggatgacttgcctaag
gaaaagctcaaagaactaatttttgaagagactgctagattccagccaggatacagatct
taa |