 | | NETWORK: N01781 | |
| Entry |
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| Name |
Activation of LXRs by oxysterols
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| Definition |
Cholesterol -- CH25H -> 25HC -> LXR => TGFB1,ABCA1,ALOX15,MERTK |
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| Expanded |
C00187 -- 9023 -> C15519 -> 10062 => 7040,19,246,10461 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 9023 | CH25H; cholesterol 25-hydroxylase |
| 10062 | NR1H3; nuclear receptor subfamily 1 group H member 3 |
| 7040 | TGFB1; transforming growth factor beta 1 |
| 19 | ABCA1; ATP binding cassette subfamily A member 1 |
| 246 | ALOX15; arachidonate 15-lipoxygenase |
| 10461 | MERTK; MER proto-oncogene, tyrosine kinase |
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| Metabolite |
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| Reference |
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| Authors |
Madenspacher JH, Morrell ED, Gowdy KM, McDonald JG, Thompson BM, Muse G, Martinez J, Thomas S, Mikacenic C, Nick JA, Abraham E, Garantziotis S, Stapleton RD, Meacham JM, Thomassen MJ, Janssen WJ, Cook DN, Wurfel MM, Fessler MB |
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| Title |
Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. |
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| Journal |
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| Reference |
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| Authors |
Mota AC, Dominguez M, Weigert A, Snodgrass RG, Namgaladze D, Brune B |
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| Title |
Lysosome-Dependent LXR and PPARdelta Activation Upon Efferocytosis in Human Macrophages. |
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| Journal |
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| Reference |
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| Authors |
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M |
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| Title |
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease. |
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| Journal |
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| Reference |
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| Authors |
Snodgrass RG, Benatzy Y, Schmid T, Namgaladze D, Mainka M, Schebb NH, Lutjohann D, Brune B |
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| Title |
Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. |
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| Journal |
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| LinkDB |
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