Homo sapiens (human): 10461
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Entry
10461 CDS
T01001
Symbol
MERTK, MER, RP38, Tyro12, c-Eyk, c-mer
Name
(RefSeq) MER proto-oncogene, tyrosine kinase
KO
K05117
c-mer proto-oncogene tyrosine kinase [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
Network
nt06535
Efferocytosis
Element
N01751
Macrophage EPO signaling
N01762
MERTK-mediated recognition and engulfment
N01775
Inactivation of CaMKII by inducing SERCA2
N01781
Activation of LXRs by oxysterols
Disease
H00527
Retinitis pigmentosa
Drug target
Zanzalintinib (
DG03273
):
D12650
D12651
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
10461 (MERTK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
10461 (MERTK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
10461 (MERTK)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
AXL family
10461 (MERTK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Ig_3
fn3
Ig_2
ig
I-set
V-set
Ig_6
Pkinase_fungal
DUF4833
Motif
Other DBs
NCBI-GeneID:
10461
NCBI-ProteinID:
NP_006334
OMIM:
604705
HGNC:
7027
Ensembl:
ENSG00000153208
Pharos:
Q12866
(Tchem)
UniProt:
Q12866
Structure
PDB
LinkDB
All DBs
Position
2:111898607..112029561
Genome browser
AA seq
999 aa
AA seq
DB search
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
NT seq
3000 nt
NT seq
+upstream
nt +downstream
nt
atggggccggccccgctgccgctgctgctgggcctcttcctccccgcgctctggcgtaga
gctatcactgaggcaagggaagaagccaagccttacccgctattcccgggaccttttcca
gggagcctgcaaactgaccacacaccgctgttatcccttcctcacgccagtgggtaccag
cctgccttgatgttttcaccaacccagcctggaagaccacatacaggaaacgtagccatt
ccccaggtgacctctgtcgaatcaaagcccctaccgcctcttgccttcaaacacacagtt
ggacacataatactttctgaacataaaggtgtcaaatttaattgctcaatcagtgtacct
aatatataccaggacaccacaatttcttggtggaaagatgggaaggaattgcttggggca
catcatgcaattacacagttttatccagatgatgaagttacagcaataatcgcttccttc
agcataaccagtgtgcagcgttcagacaatgggtcgtatatctgtaagatgaaaataaac
aatgaagagatcgtgtctgatcccatctacatcgaagtacaaggacttcctcactttact
aagcagcctgagagcatgaatgtcaccagaaacacagccttcaacctcacctgtcaggct
gtgggcccgcctgagcccgtcaacattttctgggttcaaaacagtagccgtgttaacgaa
cagcctgaaaaatccccctccgtgctaactgttccaggcctgacggagatggcggtcttc
agttgtgaggcccacaatgacaaagggctgaccgtgtccaagggagtgcagatcaacatc
aaagcaattccctccccaccaactgaagtcagcatccgtaacagcactgcacacagcatt
ctgatctcctgggttcctggttttgatggatactccccgttcaggaattgcagcattcag
gtcaaggaagctgatccgctgagtaatggctcagtcatgatttttaacacctctgcctta
ccacatctgtaccaaatcaagcagctgcaagccctggctaattacagcattggtgtttcc
tgcatgaatgaaataggctggtctgcagtgagcccttggattctagccagcacgactgaa
ggagccccatcagtagcacctttaaatgtcactgtgtttctgaatgaatctagtgataat
gtggacatcagatggatgaagcctccgactaagcagcaggatggagaactggtgggctac
cggatatcccacgtgtggcagagtgcagggatttccaaagagctcttggaggaagttggc
cagaatggcagccgagctcggatctctgttcaagtccacaatgctacgtgcacagtgagg
attgcagccgtcaccagagggggagttgggcccttcagtgatccagtgaaaatatttatc
cctgcacacggttgggtagattatgccccctcttcaactccggcgcctggcaacgcagat
cctgtgctcatcatctttggctgcttttgtggatttattttgattgggttgattttatac
atctccttggccatcagaaaaagagtccaggagacaaagtttgggaatgcattcacagag
gaggattctgaattagtggtgaattatatagcaaagaaatccttctgtcggcgagccatt
gaacttaccttacatagcttgggagtcagtgaggaactacaaaataaactagaagatgtt
gtgattgacaggaatcttctaattcttggaaaaattctgggtgaaggagagtttgggtct
gtaatggaaggaaatcttaagcaggaagatgggacctctctgaaagtggcagtgaagacc
atgaagttggacaactcttcacagcgggagatcgaggagtttctcagtgaggcagcgtgc
atgaaagacttcagccacccaaatgtcattcgacttctaggtgtgtgtatagaaatgagc
tctcaaggcatcccaaagcccatggtaattttacccttcatgaaatacggggacctgcat
acttacttactttattcccgattggagacaggaccaaagcatattcctctgcagacacta
ttgaagttcatggtggatattgccctgggaatggagtatctgagcaacaggaattttctt
catcgagatttagctgctcgaaactgcatgttgcgagatgacatgactgtctgtgttgcg
gacttcggcctctctaagaagatttacagtggcgattattaccgccaaggccgcattgct
aagatgcctgttaaatggatcgccatagaaagtcttgcagaccgagtctacacaagtaaa
agtgatgtgtgggcatttggcgtgaccatgtgggaaatagctacgcggggaatgactccc
tatcctggggtccagaaccatgagatgtatgactatcttctccatggccacaggttgaag
cagcccgaagactgcctggatgaactgtatgaaataatgtactcttgctggagaaccgat
cccttagaccgccccaccttttcagtattgaggctgcagctagaaaaactcttagaaagt
ttgcctgacgttcggaaccaagcagacgttatttacgtcaatacacagttgctggagagc
tctgagggcctggcccagggctccacccttgctccactggacttgaacatcgaccctgac
tctataattgcctcctgcactccccgcgctgccatcagtgtggtcacagcagaagttcat
gacagcaaacctcatgaaggacggtacatcctgaatgggggcagtgaggaatgggaagat
ctgacttctgccccctctgctgcagtcacagctgaaaagaacagtgttttaccgggggag
agacttgttaggaatggggtctcctggtcccattcgagcatgctgcccttgggaagctca
ttgcccgatgaacttttgtttgctgacgactcctcagaaggctcagaagtcctgatgtga
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