KEGG   NETWORK: N01784
Entry
N01784                      Network                                
Name
Glucose uptake and lactate release induced by efferocytosis
Definition
SGK1 -> SLC2A1 -- Glc(outer) -> Glc(inner) >> Lactate(inner) -- SLC16A1 -> Lactate(outer)
  Expanded
6446 -> 6513 -- C00031 -> C00031 >> C00186 -- 6566 -> C00186
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
6446  SGK1; serum/glucocorticoid regulated kinase 1
6513  SLC2A1; solute carrier family 2 member 1
6566  SLC16A1; solute carrier family 16 member 1
Metabolite
C00031  D-Glucose
C00186  (S)-Lactate
Reference
PMID:30464343
  Authors
Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS
  Title
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
  Journal
Nature 563:714-718 (2018)
DOI:10.1038/s41586-018-0735-5
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:33927896
  Authors
Yurdagul A Jr
  Title
Metabolic Consequences of Efferocytosis and its Impact on Atherosclerosis.
  Journal
Immunometabolism 3:e210017 (2021)
DOI:10.20900/immunometab20210017
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