| Entry |
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| Name |
IL3 family to Jak-STAT signaling pathway
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| Definition |
(IL3/5,CSF2) -> (IL3RA,IL5RA,CSF2RA/B) -> JAK2 -> STAT5 |
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| Expanded |
(3562,3567,1437) -> (3563,3568,1438,1439) -> 3717 -> (6776,6777) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 1437 | CSF2; colony stimulating factor 2 |
| 3563 | IL3RA; interleukin 3 receptor subunit alpha |
| 3568 | IL5RA; interleukin 5 receptor subunit alpha |
| 1438 | CSF2RA; colony stimulating factor 2 receptor subunit alpha |
| 1439 | CSF2RB; colony stimulating factor 2 receptor subunit beta |
| 3717 | JAK2; Janus kinase 2 |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
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| Reference |
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| Authors |
Dougan M, Dranoff G, Dougan SK |
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| Title |
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. |
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| Journal |
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| Reference |
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| Authors |
O'Donnell KA, Guo Y, Suresh S, Updegraff BL, Zhou X |
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| Title |
Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery. |
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| Journal |
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| Reference |
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| Authors |
Pelaia C, Paoletti G, Puggioni F, Racca F, Pelaia G, Canonica GW, Heffler E |
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| Title |
Interleukin-5 in the Pathophysiology of Severe Asthma. |
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| Journal |
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| Reference |
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| Authors |
Zhan Y, Lew AM, Chopin M |
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| Title |
The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game. |
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| Journal |
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| Reference |
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| Authors |
Hercus TR, Broughton SE, Ekert PG, Ramshaw HS, Perugini M, Grimbaldeston M, Woodcock JM, Thomas D, Pitson S, Hughes T, D'Andrea RJ, Parker MW, Lopez AF |
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| Title |
The GM-CSF receptor family: mechanism of activation and implications for disease. |
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| Journal |
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| LinkDB |
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