KEGG   NETWORK: N01806
Entry
N01806                      Network                                
Name
Cobalamin (Vitamin B12) absorption
Definition
R-Cbl -- CBLIF -- CUBAM -> (R-Cbl+CBLIF)+CUBAM -> R-Cbl(endosome)+CBLIF
  Expanded
(C02823,C06453,C00194,C08230) -- 2694 -- (8029+81693) -> (C02823,C06453,C00194,C08230+2694)+(8029+81693) -> (C02823,C06453,C00194,C08230)+2694
Class
nt06538 Cobalamin transport and metabolism
Type
Reference
Pathway
hsa04977  Vitamin digestion and absorption
Gene
2694  CBLIF; cobalamin binding intrinsic factor
8029  CUBN; cubilin
81693  AMN; amnion associated transmembrane protein
Metabolite
C02823  Cyanocobalamin
C06453  Methylcobalamin
C00194  Cobamide coenzyme
C08230  Hydroxocobalamin
Reference
  Authors
Green R
  Title
Ins and outs of cellular cobalamin transport.
  Journal
Blood 115:1476-7 (2010)
DOI:10.1182/blood-2009-12-254037
Reference
  Authors
He Q, Madsen M, Kilkenney A, Gregory B, Christensen EI, Vorum H, Hojrup P, Schaffer AA, Kirkness EF, Tanner SM, de la Chapelle A, Giger U, Moestrup SK, Fyfe JC
  Title
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.
  Journal
Blood 106:1447-53 (2005)
DOI:10.1182/blood-2005-03-1197
Reference
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
  Authors
Kozyraki R, Verroust P, Cases O
  Title
Cubilin, the intrinsic factor-vitamin B12 receptor.
  Journal
Vitam Horm 119:65-119 (2022)
DOI:10.1016/bs.vh.2022.01.005
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