KEGG    Network variation - Cobalamin transport and metabolism
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ENTRYnt06538
NameCobalamin transport and metabolism
CategoryPathway view; Cofactor/vitamin metabolism
DiseaseH01277 Vitamin B12 deficiency anaemia
H02221 Methylmalonic aciduria and homocystinuria
H00174 Methylmalonic aciduria
H00183 Homocystinuria
Display drug-target relation   disease type
N01806    R-Cbl−CBLIF−CUBAM→(R-Cbl+CBLIF)+CUBA..→R-Cbl(endosome)+CB..
    IFD   CBLIF*
    IGS1     CUBN*
    IGS2     AMN*
N01807    R-Cbl(lysosome)−LMBRD1+ABCD4→R-Cbl(cyto)−ABCC1→R-Cbl(ECM)+TCN2−CD320
    MAHCF   LMBRD1*
    MAHCJ   ABCD4*
    DFNA77       ABCC1*
    TCdeficiency         TCN2*
    MMATCblR           CD320*
N01808    R-cbl(III)−MMACHC→Cbl(II)
    MAHCC   MMACHC*
N01809    MAHCC PRDX1*⫤MMACHC
N01810    (THAP11+HCFC1+ZNF1..⇒MMACHC
    MAHCX HCFC1*
N01811    Cbl(II)cyto−MMADHC→Cbl(II)mt−MMAB→AdoCbl(III)−MMAA→MMUT+AdoCbl(III)
    MAHCD   MMADHC*
    MMAcblB       MMAB*
    MMAcblA           MMAA*
    MMAmut             MMUT*
N01812    Cbl(II)−MMADHC−MTR→MTR-Cbl(II)−MTRR→MTR-MeCbl(III)
    HMAG/NTDFS     MTR*
    HMAE/NTDFS         MTRR*

Disease nameDisease category
IFDH01277Vitamin B12 deficiency anaemiaHematologic disease
IGS1H01277Vitamin B12 deficiency anaemiaHematologic disease
IGS2H01277Vitamin B12 deficiency anaemiaHematologic disease
MAHCFH02221Methylmalonic aciduria and homocystinuriaInherited metabolic disorder
MAHCJH02221Methylmalonic aciduria and homocystinuriaInherited metabolic disorder
DFNA77H00604Deafness, autosomal dominantNervous system disease
TCdeficiencyH01190Transcobalamin II deficiencyInherited metabolic disorder
MMATCblRH00174Methylmalonic aciduriaInherited metabolic disorder
MAHCCH02221Methylmalonic aciduria and homocystinuriaInherited metabolic disorder
MAHCXH02222Methylmalonic acidemia and hyperhomocysteinemia, cblX typeInherited metabolic disorder
MAHCDH02221Methylmalonic aciduria and homocystinuriaInherited metabolic disorder
MMAcblBH00174Methylmalonic aciduriaInherited metabolic disorder
MMAcblAH00174Methylmalonic aciduriaInherited metabolic disorder
MMAmutH00174Methylmalonic aciduriaInherited metabolic disorder
HMAG/NTDFSH00183HomocystinuriaInherited metabolic disorder
H00262Neural tube defects, folate-sensitiveCongenital malformation
HMAE/NTDFSH00183HomocystinuriaInherited metabolic disorder
H00262Neural tube defects, folate-sensitiveCongenital malformation