KEGG   NETWORK: N01812
Entry
N01812                      Network                                
Name
Cobalamin loading and activation of MTR
Definition
Cbl(II) -- MMADHC -- MTR -> MTR-Cbl(II) -- MTRR -> MTR-MeCbl(III)
  Expanded
C00541 -- 27249 -- 4548 -> C06409 -- 4552 -> C06410
Class
nt06538 Cobalamin transport and metabolism
Type
Reference
Pathway
hsa04980 Cobalamin transport and metabolism   
Disease
H00183 Homocystinuria   
H00262 Neural tube defects, folate-sensitive   
Gene
27249  MMADHC; metabolism of cobalamin associated D
4548  MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase
4552  MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Metabolite
C00541  Cob(II)alamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
Reference
PMID:37916782
  Authors
Mascarenhas R, Guha A, Li Z, Ruetz M, An S, Seravalli J, Banerjee R
  Title
Cobalt-Sulfur Coordination Chemistry Drives B(12) Loading onto Methionine Synthase.
  Journal
J Am Chem Soc 145:24678-24689 (2023)
DOI:10.1021/jacs.3c07941
Reference
PMID:17892308
  Authors
Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS
  Title
Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration  calorimetry.
  Journal
Biochemistry 46:11833-44 (2007)
DOI:10.1021/bi701209p
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