KEGG   Homo sapiens (human): 4552
Entry
4552              CDS       T01001                                 
Symbol
MTRR, MSR, cblE
Name
(RefSeq) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  KO
K00597  methionine synthase reductase [EC:1.16.1.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04980  Cobalamin transport and metabolism
Network
nt06538  Cobalamin transport and metabolism
  Element
N01812  Cobalamin loading and activation of MTR
Disease
H00183  Homocystinuria
H00262  Neural tube defects, folate-sensitive
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04980 Cobalamin transport and metabolism
    4552 (MTRR)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.16  Oxidizing metal ions
   1.16.1  With NAD+ or NADP+ as acceptor
    1.16.1.8  [methionine synthase] reductase
     4552 (MTRR)
SSDB
Motif
Pfam: FAD_binding_1 Flavodoxin_1 NAD_binding_1 Flavodoxin_5
Other DBs
NCBI-GeneID: 4552
NCBI-ProteinID: NP_002445
OMIM: 602568
HGNC: 7473
Ensembl: ENSG00000124275
UniProt: Q9UBK8
Structure
LinkDB
Position
5:7850859..7901113
AA seq 698 aa
MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTT
GTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGA
RHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLV
KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASL
NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI
SNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHI
PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDA
CACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTAT
TEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPI
IMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHG
ILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDV
HDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS
NT seq 2097 nt   +upstreamnt  +downstreamnt
atgaggaggtttctgttactatatgctacacagcagggacaggcaaaggccatcgcagaa
gaaatatgtgagcaagctgtggtacatggattttctgcagatcttcactgtattagtgaa
tccgataagtatgacctaaaaaccgaaacagctcctcttgttgttgtggtttctaccacg
ggcaccggagacccacccgacacagcccgcaagtttgttaaggaaatacagaaccaaaca
ctgccggttgatttctttgctcacctgcggtatgggttactgggtctcggtgattcagaa
tacacctacttttgcaatggggggaagataattgataaacgacttcaagagcttggagcc
cggcatttctatgacactggacatgcagatgactgtgtaggtttagaacttgtggttgag
ccgtggattgctggactctggccagccctcagaaagcattttaggtcaagcagaggacaa
gaggagataagtggcgcactcccggtggcatcacctgcatcctcgaggacagaccttgtg
aagtcagagctgctacacattgaatctcaagtcgagcttctgagattcgatgattcagga
agaaaggattctgaggttttgaagcaaaatgcagtgaacagcaaccaatccaatgttgta
attgaagactttgagtcctcacttacccgttcggtacccccactctcacaagcctctctg
aatattcctggtttacccccagaatatttacaggtacatctgcaggagtctcttggccag
gaggaaagccaagtatctgtgacttcagcagatccagtttttcaagtgccaatttcaaag
gcagttcaacttactacgaatgatgccataaaaaccactctgctggtagaattggacatt
tcaaatacagacttttcctatcagcctggagatgccttcagcgtgatctgccctaacagt
gattctgaggtacaaagcctactccaaagactgcagcttgaagataaaagagagcactgc
gtccttttgaaaataaaggcagacacaaagaagaaaggagctaccttaccccagcatata
cctgcgggatgttctctccagttcatttttacctggtgtcttgaaatccgagcaattcct
aaaaaggcatttttgcgagcccttgtggactataccagtgacagtgctgaaaagcgcagg
ctacaggagctgtgcagtaaacaaggggcagccgattatagccgctttgtacgagatgcc
tgtgcctgcttgttggatctcctcctcgctttcccttcttgccagccaccactcagtctc
ctgctcgaacatcttcctaaacttcaacccagaccatattcgtgtgcaagctcaagttta
tttcacccaggaaagctccattttgtcttcaacattgtggaatttctgtctactgccaca
acagaggttctgcggaagggagtatgtacaggctggctggccttgttggttgcttcagtt
cttcagccaaacatacatgcatcccatgaagacagcgggaaagccctggctcctaagata
tccatctctcctcgaacaacaaattctttccacttaccagatgacccctcaatccccatc
ataatggtgggtccaggaaccggcatagccccgtttattgggttcctacaacatagagag
aaactccaagaacaacacccagatggaaattttggagcaatgtggttgttttttggctgc
aggcataaggatagggattatctattcagaaaagagctcagacatttccttaagcatggg
atcttaactcatctaaaggtttccttctcaagagatgctcctgttggggaggaggaagcc
ccagcaaagtatgtgcaagacaacatccagcttcatggccagcaggtggcgagaatcctc
ctccaggagaacggccatatttatgtgtgtggagatgcaaagaatatggccaaggatgta
catgatgcccttgtgcaaataataagcaaagaggttggagttgaaaaactagaagcaatg
aaaaccctggccactttaaaagaagaaaaacgctaccttcaggatatttggtcataa

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