KEGG   NETWORK: N01897
Entry
N01897                      Network                                
Name
Dopamine-DRD-GNAQ/S signaling pathway
Definition
Dopamine -> DRD1/5 -> (GNAQ,GNAS,GNAL) -> (PLCB,ADCY5)
  Expanded
C03758 -> (1812,1816) -> (2776,2778,2774) -> ((23236,5330,5331,5332),111)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04728  Dopaminergic synapse
hsa04082  Neuroactive ligand signaling
Gene
1812  DRD1; dopamine receptor D1
1816  DRD5; dopamine receptor D5
2776  GNAQ; G protein subunit alpha q
2778  GNAS; GNAS complex locus
2774  GNAL; G protein subunit alpha L
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
111  ADCY5; adenylate cyclase 5
Metabolite
C03758  Dopamine
Reference
PMID:36757901
  Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
  Title
Dopamine, Immunity, and Disease.
  Journal
Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
PMID:30446950
  Authors
Klein MO, Battagello DS, Cardoso AR, Hauser DN, Bittencourt JC, Correa RG
  Title
Dopamine: Functions, Signaling, and Association with Neurological Diseases.
  Journal
Cell Mol Neurobiol 39:31-59 (2019)
DOI:10.1007/s10571-018-0632-3
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