KEGG   NETWORK: N01924
Entry
N01924                      Network                                
Name
Loricrin oligomerization with small proline-rich proteins and further stabilization
Definition
LOR+SPRR,TCHH -- TGM3 -> (LOR+SPRR,TCHH) -- TGM1 -> (IVL+LOR+SPRR,TCHH)
  Expanded
4014+6698,6700,6707,7062 -- 7053 -> (4014+6698,6700,6707,7062) -- 7051 -> (3713+4014+6698,6700,6707,7062)
Class
nt06545 Cornified envelope formation
Type
Reference
Pathway
hsa04382 Cornified envelope formation   
Disease
H00714 Vohwinkel syndrome   
H01796 Uncombable hair syndrome   
Gene
4014  LORICRIN; loricrin cornified envelope precursor protein
6698  SPRR1A; small proline rich protein 1A
6700  SPRR2A; small proline rich protein 2A
6707  SPRR3; small proline rich protein 3
7062  TCHH; trichohyalin
7053  TGM3; transglutaminase 3
7051  TGM1; transglutaminase 1
3713  IVL; involucrin
Reference
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
  Authors
Ahvazi B, Kim HC, Kee SH, Nemes Z, Steinert PM
  Title
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
  Journal
EMBO J 21:2055-67 (2002)
DOI:10.1093/emboj/21.9.2055
Reference
  Authors
Ebrahimi Samani S, Tatsukawa H, Hitomi K, Kaartinen MT
  Title
Transglutaminase 1: Emerging Functions beyond Skin.
  Journal
Int J Mol Sci 25:ijms251910306 (2024)
DOI:10.3390/ijms251910306
Reference
  Authors
Piro MC, Ventura A, Smirnov A, Saggini A, Lena AM, Mauriello A, Bianchi L, Melino G, Candi E
  Title
Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
  Journal
Int J Mol Sci 21:ijms21051566 (2020)
DOI:10.3390/ijms21051566
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