KEGG   NETWORK: N01933
Entry
N01933                      Network                                
Name
NrCAM interactions
Definition
(NRCAM,NFASC,CNTN1/2,GLDN) == NRCAM -> (ANK2/3+SPTAN1+SPTBN),(EZR+ACTB,ACTG1),KCNQ2/3
  Expanded
(4897,23114,1272,6900,342035) == 4897 -> (287,288+6709+6711,6712,57731,51332),(7430+60,71),(3785,3786)
Class
nt06546 IgSF CAM signaling
Type
Reference
Pathway
hsa04517 IGSF CAM signaling   
Gene
4897  NRCAM; neuronal cell adhesion molecule
23114  NFASC; neurofascin
1272  CNTN1; contactin 1
6900  CNTN2; contactin 2
342035  GLDN; gliomedin
287  ANK2; ankyrin 2
288  ANK3; ankyrin 3
6709  SPTAN1; spectrin alpha, non-erythrocytic 1
6711  SPTBN1; spectrin beta, non-erythrocytic 1
6712  SPTBN2; spectrin beta, non-erythrocytic 2
57731  SPTBN4; spectrin beta, non-erythrocytic 4
51332  SPTBN5; spectrin beta, non-erythrocytic 5
7430  EZR; ezrin
60  ACTB; actin beta
71  ACTG1; actin gamma 1
3785  KCNQ2; potassium voltage-gated channel subfamily Q member 2
3786  KCNQ3; potassium voltage-gated channel subfamily Q member 3
Reference
PMID:22182708
  Authors
Sakurai T
  Title
The role of NrCAM in neural development and disorders--beyond a simple glue in the brain.
  Journal
Mol Cell Neurosci 49:351-63 (2012)
DOI:10.1016/j.mcn.2011.12.002
Reference
PMID:33451101
  Authors
Kalafatakis I, Savvaki M, Velona T, Karagogeos D
  Title
Implication of Contactins in Demyelinating Pathologies.
  Journal
Life (Basel) 11:life11010051 (2021)
DOI:10.3390/life11010051
Reference
PMID:23183391
  Authors
Pollerberg GE, Thelen K, Theiss MO, Hochlehnert BC
  Title
The role of cell adhesion molecules for navigating axons: density matters.
  Journal
Mech Dev 130:359-72 (2013)
DOI:10.1016/j.mod.2012.11.002
Reference
PMID:33585481
  Authors
Duncan BW, Murphy KE, Maness PF
  Title
Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization.
  Journal
Front Cell Dev Biol 9:625340 (2021)
DOI:10.3389/fcell.2021.625340
Reference
PMID:26909348
  Authors
Leshchyns'ka I, Sytnyk V
  Title
Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.
  Journal
Front Cell Dev Biol 4:9 (2016)
DOI:10.3389/fcell.2016.00009
Reference
PMID:34975399
  Authors
Gao Y, Kong L, Liu S, Liu K, Zhu J
  Title
Impact of Neurofascin on Chronic Inflammatory Demyelinating Polyneuropathy via Changing the Node of Ranvier Function: A Review.
  Journal
Front Mol Neurosci 14:779385 (2021)
DOI:10.3389/fnmol.2021.779385
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