KEGG   NETWORK: N01957
Entry
N01957                      Network                                
Name
JAM2 interactions
Definition
(JAM2/3,VLA4) == JAM2 -> (PARD3/6+PRKCI),TJP1/2
  Expanded
((58494,83700),(3676+3688)) == 58494 -> ((56288,50855,84612,84552)+5584),(7082,9414)
Class
nt06546 IgSF CAM signaling
Type
Reference
Pathway
hsa04517 IGSF CAM signaling   
Gene
58494  JAM2; junctional adhesion molecule 2
83700  JAM3; junctional adhesion molecule 3
3676  ITGA4; integrin subunit alpha 4
3688  ITGB1; integrin subunit beta 1
56288  PARD3; par-3 family cell polarity regulator
50855  PARD6A; par-6 family cell polarity regulator alpha
84612  PARD6B; par-6 family cell polarity regulator beta
84552  PARD6G; par-6 family cell polarity regulator gamma
5584  PRKCI; protein kinase C iota
7082  TJP1; tight junction protein 1
9414  TJP2; tight junction protein 2
Reference
  Authors
Garrido-Urbani S, Bradfield PF, Imhof BA
  Title
Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
  Journal
Cell Tissue Res 355:701-15 (2014)
DOI:10.1007/s00441-014-1820-1
Reference
  Authors
Wibbe N, Ebnet K
  Title
Cell Adhesion at the Tight Junctions: New Aspects and New Functions.
  Journal
Cells 12:cells12232701 (2023)
DOI:10.3390/cells12232701
Reference
  Authors
Ebnet K
  Title
Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
  Journal
Physiol Rev 97:1529-1554 (2017)
DOI:10.1152/physrev.00004.2017
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