NETWORK: N02022
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Entry
N02022 Network
Name
Autophagosome-lysosome fusion (SNARE)
Definition
RAB7A+EPG5 == VAMP8 == SNAP29 == STX17
Expanded
7879+57724 == 8673 == 9342 == 55014
Class
nt06550
Lysosome biogenesis
Type
Reference
Pathway
hsa04142
Lysosome biogenesis
Gene
7879
RAB7A; ras-related protein Rab-7a
57724
EPG5; ectopic P granules protein 5 homolog isoform 1
8673
VAMP8; vesicle-associated membrane protein 8
9342
SNAP29; synaptosomal-associated protein 29
55014
STX17; syntaxin-17
Reference
PMID:
27588602
Authors
Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, Zhang G, Chen Y, Feng D, Hu J, Zhang H
Title
The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes.
Journal
Mol Cell 63:781-95 (2016)
DOI:
10.1016/j.molcel.2016.08.021
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