KEGG   REACTION: R00235
Entry
R00235                      Reaction                               
Name
acetate:CoA ligase (AMP-forming)
Definition
ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA
Equation
C00002 + C00033 + C00010 <=> C00020 + C00013 + C00024
Comment
two-step reaction (see R00316+R00236)
Reaction class
RC00004  C00010_C00024
RC00012  C00024_C00033
Enzyme
6.2.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00357  Methanogenesis, acetate => methane
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.1
     R00235  ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA
Orthology
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
Other DBs
RHEA: 23179
LinkDB

KEGG   RCLASS: RC00012
Entry
RC00012                     RClass                                 
Definition
C5a-C6a:S2a+*-*+O6a:C1a+O5a-C1a+O6a
Reactant pair
C00024_C00033    C00033_C03939    C00033_C04334
Related class
Reaction
R00227 R00229 R00235 R00393 R00743 R00928 R01179 R01323
R01359 R02955 R03153 R03884 R04000 R04057 R04449 R04450
R05336 R05508 R05509 R07832 R08944 R09475 R10343 R10600
R10614
Enzyme
2.3.1.187       2.8.3.1         2.8.3.3         2.8.3.8         
2.8.3.10        2.8.3.11        2.8.3.12        2.8.3.14        
2.8.3.18        2.8.3.19        2.8.3.-         3.1.2.1         
3.1.2.16        6.2.1.1         6.2.1.13        6.2.1.22        
6.2.1.35
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00620  Pyruvate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K01026  propionate CoA-transferase [EC:2.8.3.1]
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K01039  glutaconate CoA-transferase, subunit A [EC:2.8.3.12]
K01040  glutaconate CoA-transferase, subunit B [EC:2.8.3.12]
K01067  acetyl-CoA hydrolase [EC:3.1.2.1]
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01905  acetate---CoA ligase (ADP-forming) subunit alpha [EC:6.2.1.13]
K01910  [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
K13929  malonate decarboxylase alpha subunit [EC:2.3.1.187]
K18118  succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18]
K18122  4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]
K18288  itaconate CoA-transferase [EC:2.8.3.-]
K19709  acetate CoA-transferase [EC:2.8.3.8]
K22224  acetate---CoA ligase (ADP-forming) subunit beta [EC:6.2.1.13]
K24012  acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]

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