KEGG   REACTION: R00286
Entry
R00286                      Reaction                               
Name
UDP-glucose:NAD+ 6-oxidoreductase
Definition
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
Equation
C00029 + C00001 + 2 C00003 <=> C00167 + 2 C00004 + 2 C00080
Reaction class
RC00001  C00003_C00004
RC00291  C00029_C00167
Enzyme
1.1.1.22
Pathway
rn00040  Pentose and glucuronate interconversions
rn00053  Ascorbate and aldarate metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  Biosynthesis of various nucleotide sugars
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
rn01250  Biosynthesis of nucleotide sugars
Module
M00014  Glucuronate pathway (uronate pathway)
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate
M00761  Und-P-alpha-L-Ara4N biosynthesis, UDP-Glc => UDP-L-Ara4FN => Und-P-alpha-L-Ara4N
M00997  UDP-Xyl/L-Ara biosynthesis, UDP-Glc => UDP-Xyl => UDP-L-Ala
M00999  UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.22
     R00286  UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
Orthology
K00012  UDPglucose 6-dehydrogenase [EC:1.1.1.22]
Other DBs
RHEA: 23599
LinkDB

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