KEGG   REACTION: R00575
Entry
R00575                      Reaction                               
Name
HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
Definition
2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate
Equation
2 C00002 + C00064 + C00288 + C00001 <=> 2 C00008 + C00009 + C00025 + C00169
Comment
multi-step reaction (see R00256+R10948+R10949+R01395)
Reaction class
RC00002  C00002_C00008
RC00010  C00025_C00064
RC02750  C00064_C00169
Enzyme
6.3.5.5
Pathway
rn00220  Arginine biosynthesis
rn00240  Pyrimidine metabolism
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
M00978  Ornithine-ammonia cycle
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5
     R00575  2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate
Orthology
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 18636
LinkDB

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