KEGG ORTHOLOGY: K11540

ORTHOLOGY: K11540

Entry

K11540                      KO

Symbol

CAD

Name

carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]

Pathway

map00220

Arginine biosynthesis

map00240

Pyrimidine metabolism

map00250

Alanine, aspartate and glutamate metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01240

Biosynthesis of cofactors

Module

M00051

De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP

Reaction

R00256

L-glutamine amidohydrolase

R00575

HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

R01395

ATP:carbamate phosphotransferase

R01397

carbamoyl-phosphate:L-aspartate carbamoyltransferase

R01993

(S)-dihydroorotate amidohydrolase

R10948

ATP:HCO3- phosphotransferase

R10949

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
   00220 Arginine biosynthesis
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Metallo peptidases
  Family M38: beta-aspartyl dipeptidase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase

Other DBs

GO:	0004088 0004070 0004151

Genes

HSA:

790(CAD)

PTR:	470338(CAD)

PPS:	100989545(CAD)

GGO:	101138023(CAD)

PON:	100444071(CAD)

PPYG:

129030588(CAD)

NLE:	100604681(CAD)

HMH:	116480471(CAD)

SSYN:

129467619(CAD)

MCC:	699460(CAD)

MCF:	102128048(CAD)

MTHB:

126933727

MNI:	105479760(CAD)

CSAB:

103220607(CAD)

CATY:

105578472(CAD)

PANU:

100997394(CAD)

TGE:	112605411(CAD)

MLEU:

105533983(CAD)

RRO:	104668500(CAD)

RBB:	108532706(CAD)

TFN:	117062568(CAD)

PTEH:

111554402(CAD)

CANG:

105517363(CAD)

CJC:	100405052(CAD)

SBQ:	101034080(CAD)

CIMI:

108315922(CAD)

ANAN:

105733164(CAD)

CSYR:

103251601(CAD)

MMUR:

105884399(CAD)

LCAT:

123636721(CAD)

PCOQ:

105816938(CAD)

OGA:	100953236(CAD)

MMU:	69719(Cad)

MCAL:

110294100(Cad)

MPAH:

110324844(Cad)

RNO:	24240(Cad)

MCOC:

116079655(Cad)

ANU:	117716943(Cad)

MUN:	110547690(Cad)

CGE:	100689232(Cad)

MAUA:

101843763(Cad)

PROB:

127220084(Cad)

PLEU:

114696717(Cad)

MORG:

121433026 121439634

MFOT:

126492237

AAMP:

119806436(Cad)

NGI:	103735684(Cad)

HGL:	101710382(Cad)

CPOC:

100727133(Cad)

CCAN:

109679699(Cad)

DORD:

105983698(Cad)

DSP:	122122523(Cad)

PLOP:

125356640(Cad)

NCAR:

124962757

MMMA:

107137422(Cad)

OCU:

100352236

OPI:	101536661(CAD)

TUP:	102478104(CAD)

GVR:	103600395(CAD)

CFA:	483009(CAD)

CLUD:

112664634(CAD)

VVP:	112908478(CAD)

VLG:	121490826(CAD)

NPO:	129511123(CAD)

AML:	100465885(CAD)

UMR:

103671649

UAH:	113271052(CAD)

UAR:	123799913(CAD)

ELK:

111158365

LLV:

125108295

MPUF:

101676555(CAD)

MNP:	132021217(CAD)

MLK:	131840626(CAD)

NVS:	122915225(CAD)

ORO:	101382379(CAD)

EJU:	114205877(CAD)

ZCA:	113938732(CAD)

MLX:	118007689(CAD)

NSU:	110587291(CAD)

LWW:	102745802(CAD)

FCA:	101091102(CAD)

PYU:	121044255(CAD)

PCOO:

112864353(CAD)

PBG:	122497338(CAD)

PVIV:

125161841(CAD)

LRUF:

124503295

PTG:	102971909(CAD)

PPAD:

109266874(CAD)

PUC:

125937592

AJU:

106967912

HHV:	120235931(CAD)

BTA:	504261(CAD)

BOM:	102271526(CAD)

BIU:	109566291(CAD)

BBUB:

102389153(CAD)

BBIS:

104989128(CAD)

CHX:	102179779(CAD)

OAS:	101115776(CAD)

BTAX:

128055081(CAD)

ODA:	120851563(CAD)

CCAD:

122441948 122441949

MBEZ:

129539167(CAD)

SSC:	100624530(CAD)

CFR:	102513447(CAD)

CBAI:

105063833(CAD)

CDK:	105098535(CAD)

VPC:	102528462(CAD)

BACU:

103012656(CAD)

BMUS:

118905812(CAD)

LVE:	103070440(CAD)

OOR:	101271999(CAD)

DLE:	111174963(CAD)

PCAD:

102988062(CAD)

PSIU:

116764433(CAD)

NASI:

112412797(CAD)

ECB:	100055366(CAD)

EPZ:	103546468(CAD)

EAI:	106837038(CAD)

MYB:	102255715(CAD)

MYD:	102767883(CAD)

MMYO:

118669180(CAD)

MLF:	102440221(CAD)

MDT:	132213544(CAD)

PKL:	118717193(CAD)

EFUS:

103305521(CAD)

MNA:	107534438(CAD)

DRO:	112297782(CAD)

SHON:

119001345(CAD)

AJM:	119050384(CAD)

PDIC:

114498575(CAD)

PHAS:

123822469(CAD)

MMF:	118630710(CAD)

PPAM:

129066910(CAD)

HAI:	109380279(CAD)

RFQ:	117033242(CAD)

PALE:

102896266(CAD)

PGIG:

120621846(CAD)

PVP:	105289732(CAD)

RAY:	107502147(CAD)

MJV:	108391199(CAD)

TOD:	119259464(CAD)

SARA:

101556833(CAD)

SETR:

126023848(CAD)

LAV:	100656120(CAD)

TMU:

101359976

ETF:	101650987(CAD)

DNM:	101434818(CAD)

MDO:	100026061(CAD)

GAS:	123234990(CAD)

SHR:	100930182(CAD)

AFZ:

127548741

PCW:	110206480(CAD)

TVP:	118842377(CAD)

OAA:	100085020(CAD)

GGA:	428659(CAD)

PCOC:

116230667(CAD)

MGP:	100547622(CAD)

CJO:	107312305(CAD)

TPAI:

128082993(CAD)

LMUT:

125689345(CAD)

NMEL:

110396876(CAD)

APLA:

119716457(CAD)

ACYG:

106049900(CAD)

CATA:

118259029(CAD)

AFUL:

116488248(CAD)

TGU:	100221353(CAD)

LSR:	110478515(CAD)

SCAN:

103824593(CAD)

PMOA:

120502873(CAD)

OTC:	121336253(CAD)

PRUF:

121355675(CAD)

GFR:	102044833(CAD)

FAB:	101809093(CAD)

OMA:	130251318(CAD)

PHI:	102101862(CAD)

PMAJ:

107198724(CAD)

CCAE:

111927462(CAD)

CCW:	104684514(CAD)

CBRC:

103615210(CAD)

ETL:	114069993(CAD)

ZAB:	102074924(CAD)

ZLE:	135446278(CAD)

SVG:	106860398(CAD)

HRT:	120750298(CAD)

SATI:

136358624(CAD)

FPG:	101915663(CAD)

FCH:	102055000(CAD)

NNT:	104404545(CAD)

SHAB:

115609790(CAD)

TALA:

116965192(CAD)

ACHC:

115350975(CAD)

HLE:	104830758(CAD)

AGEN:

126046342

DPUB:

104308333(CAD)

NNI:	104009152(CAD)

AFOR:

103901427(CAD)

CLV:	102091228(CAD)

CUCA:

104068795(CAD)

CPEA:

104392375(CAD)

RTD:	128907546(CAD)

AROW:

112961056(CAD)

NPD:	112955776(CAD)

DNE:	112996580(CAD)

ASN:	102374540(CAD)

AMJ:	102564082(CAD)

CPOO:

109311574(CAD)

GGN:	109300219(CAD)

CMY:	102941481(CAD)

CCAY:

125634841(CAD)

CPIC:

101931696(CAD)

CABI:

116827143(CAD)

MRV:	120401308(CAD)

ASAO:

132761756(CAD)

PVT:	110086992(CAD)

SUND:

121931149(CAD)

PBI:	103060670(CAD)

PMUR:

107286448(CAD)

CTIG:

120309166(CAD)

TSR:	106545894(CAD)

PGUT:

117667631(CAD)

APRI:

131188957(CAD)

PTEX:

113441592(CAD)

NSS:	113414613(CAD)

VKO:	123018738(CAD)

PMUA:

114595016(CAD)

PRAF:

128411533(CAD)

ZVI:	118082583(CAD)

HCG:	128325350(CAD)

GJA:	107113765(CAD)

STOW:

125443580(CAD)

EMC:	129336255(CAD)

XLA:	108716059(cad.L)

XTR:	100125119(cad)

NPR:	108803083(CAD)

RTEM:

120935968(CAD)

BBUF:

120996996(CAD)

BGAR:

122923352 122934160(CAD)

MUO:	115466986(CAD)

GSH:	117357148(CAD)

DRE:	266992(cad)

SRX:	107727603(cad)

SANH:

107676241(cad)

SGH:

107602171

CAUA:

113051032 113120429

CGIB:

127938155 127984107

PTET:

122324972(cad)

LROH:

127182475(cad)

OMC:	131526920(cad)

PPRM:

120493808(cad)

RKG:	130103174(cad)

MAMB:

125278356(cad)

CIDE:

127501884

CERY:

137019127(cad)

MASI:

127410052 127415950

TROS:

130565431(cad)

TDW:	130434159(cad)

MANU:

129429072(cad)

IPU:

108256234

IFU:	128621636(cad)

PHYP:

113528723(cad)

SMEO:

124400907(cad)

TFD:	113643371(cad)

TVC:	132854368(cad)

TRN:	134320549(cad)

AMEX:

103044710(cad)

CMAO:

118815206(cad)

EEE:	113571203(cad)

CHAR:

105901561(cad)

TRU:	101071903(cad)

TFS:	130516171(cad)

TNG:	GSTEN00009790G001

LCO:	104928828(cad)

TBEN:

117475139(cad)

CGOB:

115028885

PGEO:

117439889(cad)

GACU:

117535928(cad)

EMAC:

134877169(cad)

ELY:	117270809(cad)

EFO:	125896704(cad)

PLEP:

121955190(cad)

SLUC:

116060328(cad)

ECRA:

117961481(cad)

ESP:	116706285(cad)

PFLV:

114572997(cad)

GAT:	120807858(cad)

PPUG:

119194586(cad)

AFB:	129107088(cad)

CLUM:

117727228(cad)

PSWI:

130202573(cad)

MSAM:

119909048(cad)

SCHU:

122863008(cad)

CUD:	121521324(cad)

ALAT:

119012526(cad)

MZE:

101477088

ONL:	100700233(cad)

OAU:	116325347(cad)

OLA:	101175119(cad)

OML:	112157887(cad)

CSAI:

133464431(cad)

XMA:	102224683(cad)

XCO:	114158728(cad)

XHE:	116734268(cad)

PRET:

103457308(cad)

PFOR:

103129222(cad)

PLAI:

106949231(cad)

PMEI:

106917232(cad)

GAF:	122825206(cad)

PPRL:

129375368(cad)

CVG:	107083521(cad)

CTUL:

119795903(cad)

GMU:	124882183(cad)

NFU:	107377848(cad)

KMR:	108247065(cad)

ALIM:

106530344(cad)

NWH:	119418633(cad)

AOCE:

111565465(cad)

CSEM:

103381268(cad)

POV:	109645101(cad)

SSEN:

122784146(cad)

HHIP:

117758003(cad)

HSP:	118099395(cad)

PPLT:

128459862(cad)

SMAU:

118290347(cad)

LCF:

108890455

SDU:	111235926(cad)

SLAL:

111672610(cad)

XGL:	120788870(cad)

HCQ:	109523514(cad)

SSCV:

125990673

SBIA:

133496534(cad)

PEE:	133416911(cad)

PTAO:

133468452(cad)

BPEC:

110167003(cad)

MALB:

109970556(cad)

BSPL:

114849631(cad)

SJO:	128377168(cad)

SASA:

106571444 106607850

STRU:

115174751 115192272(cad)

OTW:	112250349 112261904

OMY:	100135860(cpsaseii) 110522267(cad)

OGO:	123990792 124019348

ONE:	115107794 115139375(cad)

OKI:	109866262(cad) 109900780

OKE:	118386940 118398613(cad)

SALP:

111954105 112068127(cad)

SNH:	120019759 120024029

CCLU:

121548885(cad) 121552604

ELS:	105017763(cad)

SFM:	108925182(cad)

PKI:	111854017(cad)

AANG:

118229767(cad)

LOC:	102697989(cad)

PSPA:

121315552(cad)

ARUT:

117402726(cad)

PSEX:

120526095(cad)

LCM:	102353472(CAD)

CMK:	103185793(cad)

RTP:	109935824(cad)

CPLA:

122543481(cad)

HOC:	132833411(cad)

LERI:

129697189(cad)

PMRN:

116953099(CAD)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG18572(r)

DER:

6550003

DSE:

6617969

DSI:	Dsimw501_GD24842(Dsim_r)

DYA:	Dyak_GE17287

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15230

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108371347 108374780 108378251

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007153

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105675396(r)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115883357 115891909

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMAN:

MSEX:

DPL:	KGM_205071B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:	126367590 126376456

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106682238(rudimentary)

NLU:

111048445

HVI:

124367257

MQU:

128987706

PHU:	Phum_PHUM000420

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_187511

DMK:

DPZ:

PVM:

PCHN:

PMOO:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136974380(r)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_D2085.1(pyr-1)

CBR:	CBG_00515(Cbr-pyr-1)

CRQ:	GCK72_004896

NAI:	NECAME_08218

HRO:	HELRODRAFT_186717

LGI:	LOTGIDRAFT_190512

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106170881 106173663

SMM:	Smp_186670

SHX:	MS3_00005261

LLON:

135487049

NVE:	5499589 5509221

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114535055 114537690

XEN:

124450795

HMG:	100208851(cad)

HSY:

130653926

RES:

135688841

TAD:	TRIADDRAFT_29177

AQU:

100635388

CME:	CYME_CMQ255C

GSL:	Gasu_42540

CCP:	CHC_T00010056001

MBR:	MONBRDRAFT_37518

SRE:	PTSG_03067

DDI:	DDB_G0276335(pyr1-3)

DPP:	DICPUDRAFT_31008

DFA:	DFA_05982(pyr1-3)

ACAN:

ACA1_267180

GTT:	GUITHDRAFT_160213

» show all

Reference

PMID:8619816

Authors

Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M

Title

Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.

Journal

Biochem Biophys Res Commun 219:249-55 (1996)
DOI:10.1006/bbrc.1996.0213

Sequence

[hsa:790]

Reference

PMID:24332717

Authors

Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S

Title

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.

Journal

Structure 22:185-98 (2014)
DOI:10.1016/j.str.2013.10.016

Sequence

[hsa:790]

LinkDB

DBGET integrated database retrieval system