KEGG   ORTHOLOGY: K11540
Entry
K11540                      KO                                     
Symbol
CAD
Name
carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
Pathway
map00240  Pyrimidine metabolism
map00250  Alanine, aspartate and glutamate metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
Disease
H00118  Congenital disorders of glycosylation type I
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 Metallo peptidases
  Family M38: beta-aspartyl dipeptidase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Other DBs
RN: R00256 R00575 R01395 R01397 R01993 R10948 R10949
GO: 0004088 0004070 0004151
Genes
HSA: 790(CAD)
PTR: 470338(CAD)
PPS: 100989545(CAD)
GGO: 101138023(CAD)
PON: 100444071(CAD)
NLE: 100604681(CAD)
MCC: 699460(CAD)
MCF: 102128048(CAD)
CSAB: 103220607(CAD)
CATY: 105578472(CAD)
PANU: 100997394(CAD)
TGE: 112605411(CAD)
RRO: 104668500(CAD)
RBB: 108532706(CAD)
TFN: 117062568(CAD)
PTEH: 111554402(CAD)
CJC: 100405052(CAD)
SBQ: 101034080(CAD)
CSYR: 103251601(CAD)
MMUR: 105884399(CAD)
OGA: 100953236(CAD)
MMU: 69719(Cad)
MCAL: 110294100(Cad)
MPAH: 110324844(Cad)
RNO: 24240(Cad)
MCOC: 116079655(Cad)
MUN: 110547690(Cad)
CGE: 100689232(Cad)
PLEU: 114696717(Cad)
NGI: 103735684(Cad)
HGL: 101710382(Cad)
CPOC: 100727133(Cad)
CCAN: 109679699(Cad)
DORD: 105983698(Cad)
DSP: 122122523(Cad)
NCAR: 124962757
OCU: 100352236(CAD)
OPI: 101536661(CAD)
TUP: 102478104(CAD)
CFA: 483009(CAD)
VVP: 112908478(CAD)
VLG: 121490826(CAD)
AML: 100465885(CAD)
UMR: 103671649(CAD)
UAH: 113271052(CAD)
UAR: 123799913(CAD)
ELK: 111158365
LLV: 125108295
MPUF: 101676555(CAD)
ORO: 101382379(CAD)
EJU: 114205877(CAD)
ZCA: 113938732(CAD)
MLX: 118007689(CAD)
FCA: 101091102(CAD)
PYU: 121044255(CAD)
PBG: 122497338(CAD)
PTG: 102971909(CAD)
PPAD: 109266874(CAD)
AJU: 106967912(CAD)
HHV: 120235931(CAD)
BTA: 504261(CAD)
BOM: 102271526(CAD)
BIU: 109566291(CAD)
BBUB: 102389153(CAD)
CHX: 102179779(CAD)
OAS: 101115776(CAD)
ODA: 120851563(CAD)
SSC: 100624530(CAD)
CFR: 102513447(CAD)
CBAI: 105063833(CAD)
CDK: 105098535(CAD)
VPC: 102528462(CAD)
BACU: 103012656(CAD)
LVE: 103070440(CAD)
OOR: 101271999(CAD)
DLE: 111174963(CAD)
PCAD: 102988062(CAD)
PSIU: 116764433(CAD)
ECB: 100055366(CAD)
EPZ: 103546468(CAD)
EAI: 106837038(CAD)
MYB: 102255715(CAD)
MYD: 102767883(CAD)
MMYO: 118669180(CAD)
MLF: 102440221(CAD)
MNA: 107534438(CAD)
PKL: 118717193(CAD)
HAI: 109380279(CAD)
DRO: 112297782(CAD)
SHON: 119001345(CAD)
AJM: 119050384(CAD)
PDIC: 114498575(CAD)
PHAS: 123822469(CAD)
MMF: 118630710(CAD)
RFQ: 117033242(CAD)
PALE: 102896266(CAD)
PGIG: 120621846(CAD)
PVP: 105289732(CAD)
RAY: 107502147(CAD)
MJV: 108391199(CAD)
TOD: 119259464(CAD)
SARA: 101556833(CAD)
LAV: 100656120(CAD)
TMU: 101359976
DNM: 101434818(CAD)
MDO: 100026061(CAD)
GAS: 123234990(CAD)
SHR: 100930182(CAD)
PCW: 110206480(CAD)
OAA: 100085020(CAD)
GGA: 428659(CAD)
PCOC: 116230667(CAD)
MGP: 100547622(CAD)
CJO: 107312305(CAD)
NMEL: 110396876(CAD)
ACYG: 106049900(CAD)
AFUL: 116488248(CAD)
TGU: 100221353(CAD)
LSR: 110478515(CAD)
SCAN: 103824593(CAD)
PMOA: 120502873(CAD)
OTC: 121336253(CAD)
PRUF: 121355675(CAD)
GFR: 102044833(CAD)
FAB: 101809093(CAD)
PHI: 102101862(CAD)
PMAJ: 107198724(CAD)
CCAE: 111927462(CAD)
CCW: 104684514(CAD)
ETL: 114069993(CAD)
ZAB: 102074924(CAD)
FPG: 101915663(CAD)
FCH: 102055000(CAD)
CLV: 102091228(CAD)
NNI: 104009152(CAD)
TALA: 116965192(CAD)
ACHC: 115350975(CAD)
AROW: 112961056(CAD)
NPD: 112955776(CAD)
DNE: 112996580(CAD)
ASN: 102374540(CAD)
AMJ: 102564082(CAD)
CPOO: 109311574(CAD)
GGN: 109300219(CAD)
CMY: 102941481(CAD)
CPIC: 101931696(CAD)
CABI: 116827143(CAD)
MRV: 120401308(CAD)
PVT: 110086992(CAD)
SUND: 121931149(CAD)
PBI: 103060670(CAD)
PMUR: 107286448(CAD)
TSR: 106545894(CAD)
PGUT: 117667631(CAD)
VKO: 123018738(CAD)
PMUA: 114595016(CAD)
ZVI: 118082583(CAD)
GJA: 107113765(CAD)
XLA: 108716059(cad.L)
XTR: 100125119(cad)
NPR: 108803083(CAD)
RTEM: 120935968(CAD)
BBUF: 120996996(CAD)
BGAR: 122923352 122934160(CAD)
DRE: 266992(cad)
SRX: 107727603(cad)
SANH: 107676241(cad)
SGH: 107602171
IPU: 108256234(cad)
PHYP: 113528723(cad)
SMEO: 124400907(cad)
TFD: 113643371(cad)
AMEX: 103044710(cad)
EEE: 113571203(cad)
TRU: 101071903(cad)
LCO: 104928828(cad)
CGOB: 115028885
ELY: 117270809(cad)
PLEP: 121955190(cad)
SLUC: 116060328(cad)
ECRA: 117961481(cad)
PFLV: 114572997(cad)
GAT: 120807858(cad)
PPUG: 119194586(cad)
MSAM: 119909048(cad)
CUD: 121521324(cad)
MZE: 101477088
ONL: 100700233(cad)
OAU: 116325347(cad)
OLA: 101175119(cad)
OML: 112157887(cad)
XMA: 102224683(cad)
XCO: 114158728(cad)
XHE: 116734268(cad)
PRET: 103457308(cad)
PFOR: 103129222(cad)
PLAI: 106949231(cad)
PMEI: 106917232(cad)
GAF: 122825206(cad)
CVG: 107083521(cad)
CTUL: 119795903(cad)
GMU: 124882183(cad)
NFU: 107377848(cad)
KMR: 108247065(cad)
ALIM: 106530344(cad)
NWH: 119418633(cad)
AOCE: 111565465(cad)
CSEM: 103381268(cad)
POV: 109645101(cad)
SSEN: 122784146(cad)
HHIP: 117758003(cad)
LCF: 108890455(cad)
SDU: 111235926(cad)
SLAL: 111672610(cad)
XGL: 120788870(cad)
HCQ: 109523514(cad)
BPEC: 110167003(cad)
MALB: 109970556(cad)
OMY: 100135860(cpsaseii) 110522267(cad)
ONE: 115107794 115139375(cad)
SALP: 111954105 112068127(cad)
ELS: 105017763(cad)
SFM: 108925182(cad)
PKI: 111854017(cad)
AANG: 118229767(cad)
LOC: 102697989(cad)
PSPA: 121315552(cad)
ARUT: 117402726(cad)
LCM: 102353472(CAD)
CMK: 103185793(cad)
RTP: 109935824
BFO: 118409817
BBEL: 109481007
CIN: 108949273
SCLV: 120335598
SPU: 580997
APLC: 110988169
SKO: 100373224
DME: Dmel_CG18572(r)
DER: 6550003
DSE: 6617969
DSI: Dsimw501_GD24842(Dsim_r)
DAN: 6504506
DSR: 110184346
DPE: 6598264
DMN: 108158165
DWI: 6641338
DGR: 6564580
DAZ: 108618190
DNV: 115565029
DHE: 111598350
DVI: 6631988
CCAT: 101452837
BOD: 106624794
MDE: 101901505
SCAC: 106092204
LCQ: 111674829
ACOZ: 120949972
AARA: 120906175
AAG: 5572005
CPII: 120432271
CNS: 116343758
AME: 410408
ACER: 108002626
ALAB: 122717621
BIM: 100743881
BBIF: 117216456
BVK: 117237966
BVAN: 117154750
BTER: 100643742
BPYO: 122574071
CCAL: 108632047
OBB: 114879302
MGEN: 117222543
NMEA: 116428453
CGIG: 122401733
SOC: 105197003
MPHA: 105840778
AEC: 105153614
ACEP: 105618642
VEM: 105561045
HST: 105191437
DQU: 106741586
CFO: 105257739
FEX: 115242940
LHU: 105675396
PGC: 109855546
OBO: 105280338
PCF: 106786608
PFUC: 122522577
VPS: 122636605
NVI: 100678143
CSOL: 105361904
TPRE: 106658586
MDL: 103569765
CGLO: 123274218
FAS: 105270378
DAM: 107043801
CCIN: 107272441
TCA: 660900
DPA: 109533123
ATD: 109595615
CSET: 123313428
AGB: 108904276
LDC: 111505021
NVL: 108556632
APLN: 108745207
PPYR: 116176322
OTU: 111425985
BMAN: 114251567
MSEX: 115443182
BANY: 112051973
PMAC: 106710718
PPOT: 106109245
PXU: 106128253
PRAP: 110992680
ZCE: 119834857
HAW: 110370025
TNL: 113504558
OFU: 114353970
API: 100163703
DNX: 107170492
AGS: 114131175
RMD: 113555003
BTAB: 109033141
CLEC: 106663568
HHAL: 106682238
NLU: 111048445
FOC: 113210221
ZNE: 110834919
CSEC: 111872620
FCD: 110863058
DMK: 116934362
PVM: 113813772
PCHN: 125029953
PCLA: 123768968
PTRU: 123502568
HAZT: 108679055
EAF: 111703810
DSV: 119466399
RSAN: 119372514
VDE: 111253013
VJA: 111266376
TUT: 107362966
DPTE: 113795876
DFR: 124499564
CSCU: 111627119
PTEP: 107440496
SDM: 118195139
CEL: CELE_D2085.1(pyr-1)
CBR: CBG_00515(Cbr-pyr-1)
PCAN: 112573344
BGT: 106065454
GAE: 121374889
HRF: 124133165
HRJ: 124262101
CRG: 105319299
MYI: 110450403
PMAX: 117344715
MMER: 123527031
OBI: 106882594
OSN: 115211025
ATEN: 116308028
ADF: 107347294
AMIL: 114948167
PDAM: 113680153
SPIS: 111336945
XEN: 124450795
HMG: 100208851(cad)
AQU: 100635388
DDI: DDB_G0276335(pyr1-3)
DFA: DFA_05982(pyr1-3)
 » show all
Reference
PMID:8619816
  Authors
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M
  Title
Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
  Journal
Biochem Biophys Res Commun 219:249-55 (1996)
DOI:10.1006/bbrc.1996.0213
  Sequence
[hsa:790]
Reference
  Authors
Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S
  Title
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.
  Journal
Structure 22:185-98 (2014)
DOI:10.1016/j.str.2013.10.016
  Sequence
[hsa:790]
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