KEGG REACTION: R01221

REACTION: R01221

Entry

R01221                      Reaction

Name

glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding);
glycine cleavage system

Definition

Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+

Equation

C00037 + C00101 + C00003 <=> C00143 + C00014 + C00011 + C00004 + C00080

Comment

multienzyme system
multi-step reaction (see R03425+R04125+R03815)

Reaction class

RC00001

C00003_C00004

RC00022

C00101_C00143

RC02834

C00014_C00037

Enzyme

1.4.1.27

Pathway

rn00630

Glyoxylate and dicarboxylate metabolism

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

rn01200

Carbon metabolism

Module

M00532

Photorespiration

M00621

Glycine cleavage system

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.27
     R01221  Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+

Orthology

K00281

glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]

K00282

glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]

K00283

glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]

K00382

dihydrolipoyl dehydrogenase [EC:1.8.1.4]

K00605

glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]

K02437

glycine cleavage system H protein

Other DBs

RHEA:

27761

LinkDB

RCLASS: RC02834