KEGG   REACTION: R01978
Entry
R01978                      Reaction                               

Name
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Equation
Comment
possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
Reaction class
RC00004  C00010_C00024
RC00503  C00332_C00356
Enzyme
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Other DBs
RHEA: 10191
LinkDB

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