KEGG   REACTION: R02081
Entry
R02081                      Reaction                               
Name
(R)-mevalonate:NAD+ oxidoreductase (CoA-acetylating)
Definition
(R)-Mevalonate + CoA + 2 NAD+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
Equation
C00418 + C00010 + 2 C00003 <=> C00356 + 2 C00004 + 2 C00080
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00356
RC00644  C00356_C00418
Enzyme
1.1.1.88
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.88
     R02081  (R)-Mevalonate + CoA + 2 NAD+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
Orthology
K00054  hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]
Other DBs
RHEA: 14836
LinkDB

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