KEGG   REACTION: R02133
Entry
R02133                      Reaction                               
Name
thiamin hydrolase
Definition
Thiamine + H2O <=> 4-Amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-Hydroxyethyl)-4-methylthiazole + H+
Equation
C00378 + C00001 <=> C01279 + C04294 + C00080
Reaction class
RC00224  C00378_C04294
RC00652  C00378_C01279
Enzyme
3.5.99.2
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.99  In other compounds
    3.5.99.2
     R02133  Thiamine + H2O <=> 4-Amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-Hydroxyethyl)-4-methylthiazole + H+
Orthology
K00877  hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 3.5.99.2]
K03707  thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
Other DBs
RHEA: 17512
LinkDB

KEGG   RCLASS: RC00224
Entry
RC00224                     RClass                                 
Definition
N5x-N5y:*-C1b:C8x+C8y-C8x+C8y
Reactant pair
C00378_C04294    C01081_C04327
Related class
Reaction
R02133 R02863 R03223
Enzyme
2.5.1.2         2.5.1.3         3.5.99.2
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00788  thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]
K00877  hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 3.5.99.2]
K03707  thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
K10811  thiamine pyridinylase [EC:2.5.1.2]
K14153  hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3]
K14154  thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase [EC:2.5.1.3 2.7.1.50]
K21219  hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3]
K21220  thiamine-phosphate diphosphorylase [EC:2.5.1.3]

KEGG   RCLASS: RC00652
Entry
RC00652                     RClass                                 
Definition
C1b-C1b:N5y+*-*+O1a:C8y-C8y
Reactant pair
C00378_C01279
Related class
Reaction
R02133
Enzyme
3.5.99.2
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00877  hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 3.5.99.2]
K03707  thiaminase (transcriptional activator TenA) [EC:3.5.99.2]

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