KEGG   REACTION: R02501
Entry
R02501                      Reaction                               
Name
testosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Testosterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxytestosterone + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00535 + C03024 + C00007 <=> C05294 + C03161 + C00001
Comment
aromatase, ARO
three successive reactions (R02501+R04761+R03087)
subsequently R04761
Reaction class
RC00257  C00535_C05294
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R02501  Testosterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxytestosterone + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38182
LinkDB

KEGG   REACTION: R04761
Entry
R04761                      Reaction                               
Name
19-hydroxytestosterone,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase
Definition
19-Hydroxytestosterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxotestosterone + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C05294 + C03024 + C00007 <=> C05295 + C03161 + 2 C00001
Comment
aromatase, ARO
following after R02501
subsequently R03087
Reaction class
RC00893  C05294_C05295
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R04761  19-Hydroxytestosterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxotestosterone + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38186
LinkDB

KEGG   REACTION: R03087
Entry
R03087                      Reaction                               
Name
19-oxotestosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)
Definition
19-Oxotestosterone + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estradiol-17beta + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05295 + C00007 + C03024 <=> C00951 + C00058 + C03161 + C00001
Comment
aromatase, ARO
following after R04761
Reaction class
RC02649  C00951_C05295
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R03087  19-Oxotestosterone + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estradiol-17beta + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38190
LinkDB

DBGET integrated database retrieval system