KEGG   REACTION: R03124
Entry
R03124                      Reaction                               
Name
dihydrokaempferol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)
Definition
Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00974 + C03024 + C00007 <=> C01617 + C03161 + C00001
Comment
the first step of two-step reaction (see R03125, R03124+R03639)
subsequently R03639, catalyzed by flavonoid 3',5'-hydroxylase (ec 1.14.13.88)
Reaction class
RC00046  C00974_C01617
Enzyme
1.14.14.81      1.14.14.82
Pathway
rn00941  Flavonoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.81
     R03124  Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.82
     R03124  Dihydrokaempferol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Taxifolin + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.81
   R07369  Flavanone <=> 3'-Hydroxyflavanone
    R03124  Dihydrokaempferol <=> Taxifolin
  1.14.14.82
   R03615  Flavonoid <=> 3'-Hydroxyflavonoid
    R03124  Dihydrokaempferol <=> Taxifolin
Orthology
K05280  flavonoid 3'-monooxygenase [EC:1.14.14.82]
K13083  flavonoid 3',5'-hydroxylase [EC:1.14.14.81]
Other DBs
RHEA: 61115
LinkDB

KEGG   REACTION: R03639
Entry
R03639                      Reaction                               
Name
taxifolin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Definition
Taxifolin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Dihydromyricetin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C01617 + C03024 + C00007 <=> C02906 + C03161 + C00001
Comment
flavonoid 3',5'-hydroxylase
flavonoid 3',5'-monooxygenase
second step of two-step reaction (see R03125, R03124+R03639)
Reaction class
RC00046  C01617_C02906
Enzyme
1.14.14.81
Pathway
rn00941  Flavonoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.81
     R03639  Taxifolin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Dihydromyricetin + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.81
   R07370  3'-Hydroxyflavanone <=> 3',5'-Dihydroxyflavanone
    R03639  Taxifolin <=> Dihydromyricetin
Orthology
K13083  flavonoid 3',5'-hydroxylase [EC:1.14.14.81]
Other DBs
RHEA: 61119
LinkDB

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