REACTION: R04426
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Entry
R04426 Reaction
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Equation
C04411
+
C00003
<=>
C04236
+
C00004
+
C00080
Comment
subsequently
R01652
Reaction class
RC00001
C00003_C00004
RC00084
C04236_C04411
Enzyme
1.1.1.85
Pathway
rn00290
Valine, leucine and isoleucine biosynthesis
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
rn01210
2-Oxocarboxylic acid metabolism
Module
M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.85
R04426 (2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
BRITE hierarchy
Orthology
K00052
3-isopropylmalate dehydrogenase [EC:
1.1.1.85
]
K21360
3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:
1.1.1.85
1.1.1.-]
Other DBs
RHEA:
10895
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