KEGG REACTION: R04639

REACTION: R04639

Entry

R04639                      Reaction

Name

2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate hydrolase

Definition

7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

Equation

C04895 + C00001 <=> C06148

Comment

the last step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
possibly spontaneous
following after R05048

Reaction class

RC01188

C04895_C06148

Enzyme

3.5.4.16

Pathway

rn00790

Folate biosynthesis

rn01100

Metabolic pathways

Module

M00126

Tetrahydrofolate biosynthesis, GTP => THF

M00841

Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF

M00842

Tetrahydrobiopterin biosynthesis, GTP => BH4

M00843

L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4

M00988

PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine

Brite

Enzymatic reactions [BR:br08201]
3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R04639  7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

Orthology

K01495

GTP cyclohydrolase IA [EC:3.5.4.16]

K09007

GTP cyclohydrolase IB [EC:3.5.4.16]

K22391

GTP cyclohydrolase I [EC:3.5.4.16]

LinkDB

RCLASS: RC01188