 | | REACTION: R04813 | |
| Entry |
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| Name |
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
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| Definition |
(24R,25R)-3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA <=> (24E)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
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| Equation |
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| Reaction class |
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| Enzyme |
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| Pathway |
| rn00120 | Primary bile acid biosynthesis |
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| Module |
| M00104 | Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate |
| M00862 | beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA |
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| Brite |
Enzymatic reactions [BR:br08201]
4. Lyase reactions
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.107
R04813 (24R,25R)-3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA <=> (24E)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
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| Orthology |
| K12405 | (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119] |
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| Reference |
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| Authors |
Russell DW |
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| Title |
The enzymes, regulation, and genetics of bile acid synthesis. |
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| Journal |
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| Reference |
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| Authors |
Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T. |
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| Title |
Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis. |
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| LinkDB |
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