KEGG   REACTION: R05046
Entry
R05046                      Reaction                               
Name
formamidopyrimidine nucleoside triphosphate amidohydrolase
Definition
Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate
Equation
C05922 + C00001 <=> C05923 + C00058
Comment
the second step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
following after R00428
subsequently R05048
Reaction class
RC00263  C05922_C05923
RC00323  C00058_C05922
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
M00988  PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R05046  Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
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