KEGG   REACTION: R05520
Entry
R05520                      Reaction                               
Name
S-adenosyl-L-methionine:erythromycin-C 3''-O-methyltransferase
Definition
S-Adenosyl-L-methionine + Erythromycin C <=> S-Adenosyl-L-homocysteine + Erythromycin
Equation
C00019 + C06616 <=> C00021 + C01912
Comment
EryG: O-methyltransferase
Reaction class
RC00003  C00019_C00021
RC01324  C01912_C06616
Enzyme
2.1.1.254
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.254
     R05520  S-Adenosyl-L-methionine + Erythromycin C <=> S-Adenosyl-L-homocysteine + Erythromycin
Orthology
K14369  erythromycin 3''-O-methyltransferase [EC:2.1.1.254]
Reference
1  [PMID:9353926]
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
Reference
2  [PMID:1840640]
  Authors
Haydock SF, Dowson JA, Dhillon N, Roberts GA, Cortes J, Leadlay PF
  Title
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.
  Journal
Mol Gen Genet 230:120-8 (1991)
DOI:10.1007/BF00290659
Other DBs
RHEA: 32650
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