| Entry |
|
|---|
| Name |
Erythromycin;
Erythromycin A;
Abomacetin
|
|---|
| Formula |
C37H67NO13
|
|---|
| Exact mass |
733.4612
|
|---|
| Mol weight |
733.9268
|
|---|
| Structure |
|
|---|
| Sequence |
0 Pyk 1 Mtk 2 Mtn 3 Mte 4 Mtk 5 Mtk 6 Mtn |
|---|
| Gene |
|
|---|
| Organism |
[1] Aeromicrobium erythreum
[2] Saccharopolyspora erythraea (Streptomyces erythraeus)
[3] Micromonospora megalomicea subsp. nigra. |
|---|
| Type |
PK |
|---|
| Remark |
|
|---|
| Reaction |
|
|---|
| Pathway |
| map00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| map01110 | Biosynthesis of secondary metabolites |
|
|---|
| Module |
| M00774 | Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B |
|
|---|
| Enzyme |
|
|---|
| Brite |
Compounds with biological roles [BR:br08001]
Antibiotics
Polyketides and nonribosomal peptides
Macrolides
C01912 Erythromycin
Lipids [BR:br08002]
PK Polyketides
PK04 Macrolides and lactone polyketides
C01912 Erythromycin
Secondary metabolites in pathway maps [br08011.html]
Biosynthetic pathways and modules of secondary metabolites
C01912
Prodrugs [br08324.html]
C01912
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Dermatological Agents
Topical Anti-infectives
Antibacterials, dermatological
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6141 Erythromycins
D00140 Erythromycin (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D00140 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D00140 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D00140 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D00140 Erythromycin
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D00140 Erythromycin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D00140 Erythromycin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00140 Erythromycin
D00140 Erythromycin enteric-coated tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00140
Drug transporters
D00140
Prodrugs [br08324.html]
D00140
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 51
1 C1y C 28.9103 -14.0865
2 C1z C 28.9103 -12.7233
3 C1y C 27.7262 -14.7624
4 O2a O 30.8915 -14.8028
5 C1x C 27.7262 -12.0417
6 O1a O 29.9384 -11.7356
7 C1a C 30.1926 -13.1564
8 C1y C 27.7262 -16.1256
9 C1a C 26.7555 -13.7407
10 C1y C 32.4693 -14.0880
11 C1y C 27.7262 -10.6727
12 O2a O 28.4656 -17.4830
13 C1y C 26.5536 -16.8073
14 C1y C 33.6374 -14.7792
15 O2x O 32.4813 -12.7253
16 C5x C 26.5536 -9.9968
17 C1a C 28.9103 -9.9968
18 C1y C 29.9816 -17.9009
19 C7x C 25.3695 -16.1256
20 C1a C 26.5536 -18.1703
21 C1y C 34.8229 -14.1176
22 O1a O 33.6283 -16.1469
23 C1y C 33.6717 -12.0610
24 C1y C 25.3695 -10.6727
25 O5x O 26.5536 -8.6336
26 C1x C 29.9816 -19.2584
27 O2x O 31.1658 -17.2194
28 O7x O 25.3695 -14.7624
29 O6a O 24.3124 -17.0729
30 C1x C 34.8373 -12.7600
31 N1c N 35.9958 -14.8060
32 C1a C 33.6914 -10.7005
33 C1y C 25.3695 -12.0417
34 C1a C 24.1912 -9.9968
35 C1z C 31.1658 -19.9458
36 C1y C 32.3382 -17.9009
37 C1y C 24.1912 -14.0865
38 C1z C 24.1912 -12.7233
39 O1a O 26.5536 -12.7233
40 C1y C 32.3382 -19.2584
41 O2a O 31.1658 -21.2686
42 C1a C 32.6098 -20.9278
43 C1a C 33.5224 -17.2252
44 C1b C 23.0127 -14.7624
45 C1a C 22.9435 -13.2892
46 O1a O 22.9435 -12.0360
47 O1a O 33.5224 -19.9458
48 C1a C 32.2632 -22.2275
49 C1a C 23.0477 -15.8829
50 C1a C 37.2421 -14.0985
51 C1a C 35.9864 -16.1677
BOND 53
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 2 7 1 #Down
7 3 8 1
8 3 9 1 #Down
9 10 4 1 #Down
10 5 11 1
11 8 12 1 #Down
12 8 13 1
13 10 14 1
14 10 15 1
15 11 16 1
16 11 17 1 #Down
17 18 12 1 #Down
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 14 22 1 #Up
22 15 23 1
23 16 24 1
24 16 25 2
25 18 26 1
26 18 27 1
27 19 28 1
28 19 29 2
29 21 30 1
30 21 31 1 #Down
31 23 32 1 #Down
32 24 33 1
33 24 34 1 #Up
34 26 35 1
35 27 36 1
36 28 37 1
37 33 38 1
38 33 39 1 #Up
39 35 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1 #Up
43 37 44 1 #Down
44 38 45 1 #Down
45 38 46 1 #Up
46 40 47 1 #Down
47 41 48 1
48 44 49 1
49 23 30 1
50 36 40 1
51 37 38 1
52 31 50 1
53 31 51 1
|
|---|
