Entry Name dTDP-D-desosamine:3-O-mycarosylerythronolide-B 5-O-beta-D-desosaminyltransferase
Definition dTDP-D-desosamine + 3-O-alpha-Mycarosylerythronolide B <=> Erythromycin D + dTDP
Equation Comment desosaminyltransferase, EryCIII+EryCII, MegCIII+MegCII
Reaction class Enzyme Pathway rn00522 Biosynthesis of 12-, 14- and 16-membered macrolides
rn01110 Biosynthesis of secondary metabolites
Module M00774 Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Brite Enzymatic reactions [BR:br08201 ] BRITE hierarchy Orthology K14368 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278 ]
K15997 3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein
Reference Authors Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
Title Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
Journal Reference Authors Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF
Title Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII.
Journal Reference Authors Rodriguez E, Peiru S, Carney JR, Gramajo H
Title In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.
Journal Other DBs LinkDB All DBs
