KEGG   ORTHOLOGY: K14368
Entry
K14368                      KO                                     

Symbol
eryCIII
Name
3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.278  3-alpha-mycarosylerythronolide B desosaminyl transferase
     K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase
Other DBs
RN: R05531
COG: COG1819
CAZy: GT1
Genes
SEN: SACE_0726(eryCIII)
DVC: Dvina_31275
AEY: CDG81_13160
AG: AAG13921(megCIII)
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0726]
Reference
PMID:9563840
  Authors
Salah-Bey K, Doumith M, Michel JM, Haydock S, Cortes J, Leadlay PF, Raynal MC
  Title
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea.
  Journal
Mol Gen Genet 257:542-53 (1998)
DOI:10.1007/s004380050680
LinkDB

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