KEGG   REACTION: R05728
Entry
R05728                      Reaction                               
Name
(E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase
Definition
(E)-4-Hydroxyphenylacetaldehyde oxime + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (S)-4-Hydroxymandelonitrile + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C04350 + C03024 + C00007 <=> C03742 + C03161 + 2 C00001
Comment
three-step reaction (R11442+R04306+R02708)
Enzyme
1.14.14.37
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00369  Cyanogenic glycoside biosynthesis, tyrosine => dhurrin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.37
     R05728  (E)-4-Hydroxyphenylacetaldehyde oxime + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (S)-4-Hydroxymandelonitrile + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
Reference
1  [PMID:9484480]
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
Other DBs
RHEA: 18404
LinkDB

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