KEGG   REACTION: R08663
Entry
R08663                      Reaction                               
Name
L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Valine + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> (E)-2-Methylpropanal oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Equation
C00183 + 2 C00007 + 2 C03024 <=> C03219 + 2 C03161 + C00011 + 3 C00001
Comment
three-step reaction (see R10031+R10032+R10033)
The enzyme can also accept L-isoleucine as substrate, with a lower activity.(1.14.14.39)
3step reaction (similar to R00730+R04460+R07190)
Reaction class
RC00001  C00005_C00006
RC02339  C00183_C03219
Enzyme
1.14.14.38
Pathway
rn00966  Glucosinolate biosynthesis
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.38
     R08663  L-Valine + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> (E)-2-Methylpropanal oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Orthology
K13401  valine N-monooxygenase [EC:1.14.14.38]
Other DBs
RHEA: 28609
LinkDB

KEGG   REACTION: R10031
Entry
R10031                      Reaction                               
Name
L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00183 + C00007 + C03024 <=> C20313 + C03161 + C00001
Comment
the first step of three-step reaction (see R08663, R10031+R10032+R10033)
Reaction class
RC00001  C00005_C00006
RC00365  C00183_C20313
Enzyme
1.14.14.38      1.14.14.39
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.38
     R10031  L-Valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.39
     R10031  L-Valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K13401  valine N-monooxygenase [EC:1.14.14.38]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
Other DBs
RHEA: 30494
LinkDB

KEGG   REACTION: R10032
Entry
R10032                      Reaction                               
Name
N-hydroxy-L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
N-Hydroxy-L-valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N,N-Dihydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C20313 + C00007 + C03024 <=> C20314 + C03161 + C00001
Comment
the second step of three-step reaction (see R08663, R10031+R10032+R10033)
Reaction class
RC00001  C00005_C00006
RC01918  C20313_C20314
Enzyme
1.14.14.38      1.14.14.39
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.38
     R10032  N-Hydroxy-L-valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N,N-Dihydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.39
     R10032  N-Hydroxy-L-valine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N,N-Dihydroxy-L-valine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K13401  valine N-monooxygenase [EC:1.14.14.38]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
Other DBs
RHEA: 30498
LinkDB

KEGG   REACTION: R10033
Entry
R10033                      Reaction                               
Definition
N,N-Dihydroxy-L-valine <=> (E)-2-Methylpropanal oxime + CO2 + H2O
Equation
C20314 <=> C03219 + C00011 + C00001
Comment
the last step of three-step reaction (see R08663, R10031+R10032+R10033)
Reaction class
RC03009  C03219_C20314
Enzyme
1.14.14.38      1.14.14.39
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.38
     R10033  N,N-Dihydroxy-L-valine <=> (E)-2-Methylpropanal oxime + CO2 + H2O
    1.14.14.39
     R10033  N,N-Dihydroxy-L-valine <=> (E)-2-Methylpropanal oxime + CO2 + H2O
Orthology
K13401  valine N-monooxygenase [EC:1.14.14.38]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
Other DBs
RHEA: 30502
LinkDB

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