KEGG   REACTION: R08770
Entry
R08770                      Reaction                               
Name
4-hydroxy-3-all-trans-polyprenylbenzoate,ferredoxin:oxygen oxidoreductase (5-hydroxylating)
Definition
4-Hydroxy-3-polyprenylbenzoate + 2 Reduced [2Fe-2S] ferredoxin + Oxygen + 2 H+ <=> 3,4-Dihydroxy-5-polyprenylbenzoate + 2 Oxidized [2Fe-2S] ferredoxin + H2O
Equation
C05848 + 2 C22150 + C00007 + 2 C00080 <=> C17554 + 2 C22151 + C00001
Comment
general reaction (see R06865, n=5-9)
Reaction class
RC00046  C05848_C17554
Enzyme
1.14.15.45
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00128  Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate + polyprenyl-PP => ubiquinone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.45
     R08770  4-Hydroxy-3-polyprenylbenzoate + 2 Reduced [2Fe-2S] ferredoxin + Oxygen + 2 H+ <=> 3,4-Dihydroxy-5-polyprenylbenzoate + 2 Oxidized [2Fe-2S] ferredoxin + H2O
Orthology
K06126  4-hydroxy-3-polyprenylbenzoate 5-hydroxylase / 2-methoxy-6-polyprenylphenol 4-hydroxylase [EC:1.14.15.45 1.14.15.46]
Reference
1  [PMID:21944752]
  Authors
Ozeir M, Muhlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F.
  Title
Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency.
  Journal
Chem Biol 18:1134-42 (2011)
DOI:10.1016/j.chembiol.2011.07.008
Reference
2  [PMID:26808124]
  Authors
Ismail A, Leroux V, Smadja M, Gonzalez L, Lombard M, Pierrel F, Mellot-Draznieks C, Fontecave M.
  Title
Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6.
  Journal
PLoS Comput Biol 12:e1004690 (2016)
DOI:10.1371/journal.pcbi.1004690
Reference
3  [PMID:11583838]
  Authors
Meganathan R
  Title
Ubiquinone biosynthesis in microorganisms.
  Journal
FEMS Microbiol Lett 203:131-9 (2001)
DOI:10.1111/j.1574-6968.2001.tb10831.x
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