KEGG   REACTION: R10026
Entry
R10026                      Reaction                               
Name
amorpha-4,11-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)
Definition
Amorpha-4,11-diene + 3 Oxygen + 3 [Reduced NADPH---hemoprotein reductase] <=> Artemisinate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
Equation
C16028 + 3 C00007 + 3 C03024 <=> C20309 + 3 C03161 + 4 C00001
Comment
three-step reaction (see R10023+R10024+R10025)
Reaction class
RC02089  C16028_C20309
Enzyme
1.14.14.114
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.114
     R10026  Amorpha-4,11-diene + 3 Oxygen + 3 [Reduced NADPH---hemoprotein reductase] <=> Artemisinate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
Other DBs
RHEA: 33002
LinkDB

KEGG   REACTION: R10023
Entry
R10023                      Reaction                               
Name
amorpha-4,11-diene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)
Definition
Amorpha-4,11-diene + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinic alcohol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C16028 + C00007 + C03024 <=> C20307 + C03161 + C00001
Comment
the first step of three-step reaction (see R10026, R10023+R10024+R10025)
Reaction class
RC01137  C16028_C20307
Enzyme
1.14.14.114
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.114
     R10023  Amorpha-4,11-diene + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinic alcohol + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 33006
LinkDB

KEGG   REACTION: R10024
Entry
R10024                      Reaction                               
Name
artemisinic-alcohol,[reduced NADPH---hemoprotein reductase]:oxygen 12-oxidoreductase
Definition
Artemisinic alcohol + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinic aldehyde + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C20307 + C00007 + C03024 <=> C20308 + C03161 + 2 C00001
Comment
the second step of three-step reaction (see R10026, R10023+R10024+R10025)
Reaction class
RC02561  C20307_C20308
Enzyme
1.14.14.114
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.114
     R10024  Artemisinic alcohol + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinic aldehyde + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Other DBs
RHEA: 33010
LinkDB

KEGG   REACTION: R10025
Entry
R10025                      Reaction                               
Name
artemisinic-aldehyde,[reduced NADPH---hemoprotein reductase]:oxygen 12-oxidoreductase
Definition
Artemisinic aldehyde + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C20308 + C00007 + C03024 <=> C20309 + C03161 + C00001
Comment
the last step of three-step reaction (see R10026, R10023+R10024+R10025)
Reaction class
RC00254  C20308_C20309
Enzyme
1.14.14.114
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.114
     R10025  Artemisinic aldehyde + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Artemisinate + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 33014
LinkDB

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