KEGG   REACTION: R11269
Entry
R11269                      Reaction                               
Name
kanamycin-A:2-oxoglutarate aminotransferase
Definition
Kanamycin A + 2-Oxoglutarate <=> 6'-Oxokanamycin X + L-Glutamate
Equation
C01822 + C00026 <=> C21251 + C00025
Reaction class
RC00006  C00025_C00026
RC02401  C01822_C21251
Enzyme
2.6.1.94
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.94
     R11269  Kanamycin A + 2-Oxoglutarate <=> 6'-Oxokanamycin X + L-Glutamate
Orthology
K20568  neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase [EC:2.6.1.93 2.6.1.94]
Reference
1  [PMID:21983602]
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671
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