| Entry |
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| Definition |
3 Malonyl-CoA + 5 Methylmalonyl-CoA + 7 NADPH + 7 H+ <=> Protomycinolide IV + 8 CoA + 8 CO2 + 4 H2O + 7 NADP+
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| Equation |
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| Comment |
protomycinolide IV synthase,MycAI-AV
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| Pathway |
| rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| rn01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00934 | Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II |
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| Orthology |
| K24528 | protomycinolide IV synthase 1 |
| K24559 | protomycinolide IV synthase 2 |
| K24560 | protomycinolide IV synthase 3 |
| K24561 | protomycinolide IV synthase 4 |
| K24562 | protomycinolide IV synthase 5 |
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| Reference |
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| Authors |
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F. |
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| Title |
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study. |
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| Journal |
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| Reference |
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| Authors |
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F |
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| Title |
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida. |
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| Journal |
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| LinkDB |
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