| Entry |
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| Name |
3'-phosphoadenylyl-sulfate:heparosan-D-glucuronate N-sulfonotransferase
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| Definition |
3'-Phosphoadenylyl sulfate + Heparosan D-glucuronate <=> Adenosine 3',5'-bisphosphate + Heparosan-N-sulfate D-glucuronate
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| Equation |
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| Reaction class |
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| Enzyme |
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| Brite |
Enzymatic reactions [BR:br08201]
2. Transferase reactions
2.8 Transferring sulfur-containing groups
2.8.2 Sulfotransferases
2.8.2.8
R13047 3'-Phosphoadenylyl sulfate + Heparosan D-glucuronate <=> Adenosine 3',5'-bisphosphate + Heparosan-N-sulfate D-glucuronate
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| Orthology |
| K02576 | heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.5.1.- 2.8.2.8] |
| K02577 | heparan sulfate N-deacetylase/N-sulfotransferase NDST2 [EC:3.5.1.- 2.8.2.8] |
| K02578 | heparan sulfate N-deacetylase/N-sulfotransferase NDST3 [EC:3.5.1.- 2.8.2.8] |
| K02579 | heparan sulfate N-deacetylase/N-sulfotransferase NDST4 [EC:3.5.1.- 2.8.2.8] |
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| Reference |
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| Authors |
Humphries DE, Sullivan BM, Aleixo MD, Stow JL. |
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| Title |
Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. |
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| Journal |
Biochem J 325 ( Pt 2):351-7 (1997) |
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| Reference |
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| Authors |
Missaghian P, Dierker T, Khosrowabadi E, Axling F, Eriksson I, Ghanem A, Kusche-Gullberg M, Kellokumpu S, Kjellen L. |
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| Title |
A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation. |
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