KEGG   REACTION: R13117
Entry
R13117                      Reaction                               
Name
(+)-exo-beta-bergamotene,[reduced NADPH---hemoprotein reductase] oxidoreductase (5-dehydro-6-demethoxyfumagillol-producing)
Definition
(+)-exo-beta-Bergamotene + 2 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 5-Dehydro-6-demethoxyfumagillol + 2 [Oxidized NADPH---hemoprotein reductase] + 3 H2O
Equation
C22617 + 2 C03024 + 3 C00007 <=> C22629 + 2 C03161 + 3 C00001
Comment
three-step reaction (see R13118+R13119+R13120)
Enzyme
1.14.14.184
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.184
     R13117  (+)-exo-beta-Bergamotene + 2 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 5-Dehydro-6-demethoxyfumagillol + 2 [Oxidized NADPH---hemoprotein reductase] + 3 H2O
Orthology
K21295  5-dehydro-6-demethoxyfumagillol synthase [EC:1.14.14.184]
Other DBs
RHEA: 74594
LinkDB

KEGG   REACTION: R13118
Entry
R13118                      Reaction                               
Definition
(+)-exo-beta-Bergamotene + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (5R)-Hydroxy-(+)-exo-beta-bergamotene + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C22617 + C03024 + C00007 <=> C22627 + C03161 + C00001
Comment
the first step of three-step reaction (see R13117, R13118+R13119+R13120)
Enzyme
1.14.14.184
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.184
     R13118  (+)-exo-beta-Bergamotene + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (5R)-Hydroxy-(+)-exo-beta-bergamotene + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 74698
LinkDB

KEGG   REACTION: R13119
Entry
R13119                      Reaction                               
Definition
(5R)-Hydroxy-(+)-exo-beta-bergamotene + Oxygen <=> (3S)-3-[2-Methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O
Equation
C22627 + C00007 <=> C22628 + C00001
Comment
the second step of three-step reaction (see R13117, R13118+R13119+R13120)
Enzyme
1.14.14.184
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.184
     R13119  (5R)-Hydroxy-(+)-exo-beta-bergamotene + Oxygen <=> (3S)-3-[2-Methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O
Other DBs
RHEA: 74702
LinkDB

KEGG   REACTION: R13120
Entry
R13120                      Reaction                               
Definition
(3S)-3-[2-Methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-Dehydro-6-demethoxyfumagillol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C22628 + C03024 + C00007 <=> C22629 + C03161 + C00001
Comment
the last step of three-step reaction (see R13117, R13118+R13119+R13120)
Enzyme
1.14.14.184
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.184
     R13120  (3S)-3-[2-Methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-Dehydro-6-demethoxyfumagillol + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 74706
LinkDB

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