KEGG   REACTION: R13332
Entry
R13332                      Reaction                               
Name
(19E)-cura-2(16),19-dien-17-al,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)
Definition
Norfluorocurarine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 18-Hydroxynorfluorocurarine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C22923 + C03024 + C00007 <=> C22924 + C03161 + C00001
Reaction class
RC03588  C22923_C22924
Enzyme
1.14.14.188
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00980  Strychnine biosynthesis, geissoschizine => strychnine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.188
     R13332  Norfluorocurarine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 18-Hydroxynorfluorocurarine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K27782  norfluorocurarine 18-hydroxylase [EC:1.14.14.188]
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
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