KEGG   REACTION: R13344
Entry
R13344                      Reaction                               
Name
stemmadenine acetate:oxygen oxidoreductase
Definition
Stemmadenine acetate + Oxygen <=> Precondylocarpine acetate + Hydrogen peroxide
Equation
Reaction class
RC03591  C22933_C22934
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.3  With oxygen as acceptor
    1.21.3.11
     R13344  Stemmadenine acetate + Oxygen <=> Precondylocarpine acetate + Hydrogen peroxide
Orthology
K27792  precondylocarpine acetate synthase [EC:1.21.3.11]
Reference
1  [PMID:36045295]
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
LinkDB

KEGG   RCLASS: RC03591
Entry
RC03591                     RClass                                 
Definition
C1x-C2x:*-*:C2y+N1y-C2y+N2y
N1y-N2y:*-*:C1x+C1x+C1x-C1x+C1x+C2x
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K27792  precondylocarpine acetate synthase [EC:1.21.3.11]

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