KEGG   REACTION: R13348
Entry
R13348                      Reaction                               
Name
17-dehydrostemmadenine:NADP+ 3(4)-oxidoreductase
Definition
17-Dehydrostemmadenine + NADP+ <=> 3,17-Didehydrostemmadenine + NADPH
Equation
Reaction class
RC03594  C22936_C22937
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.56
     R13348  17-Dehydrostemmadenine + NADP+ <=> 3,17-Didehydrostemmadenine + NADPH
Orthology
K27789  3,17-didehydrostemmadenine reductase [EC:1.5.1.56]
Reference
1  [PMID:29511102]
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
LinkDB

DBGET integrated database retrieval system