KEGG   REACTION: R13349
Entry
R13349                      Reaction                               
Name
stemmadenine:NADP+ 17-oxidoreductase
Definition
Stemmadenine + NADP+ <=> 17-Dehydrostemmadenine + NADPH + H+
Equation
Reaction class
RC00893  C11691_C22937
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.439
     R13349  Stemmadenine + NADP+ <=> 17-Dehydrostemmadenine + NADPH + H+
Orthology
K27790  17-dehydrostemmadenine reductase [EC:1.1.1.439]
Reference
1  [PMID:29511102]
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
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